Reactome | CD46 [plasma membrane]

CD46 [plasma membrane]

Stable Identifier

R-HSA-977362

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Membrane cofactor protein, MCP_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P78504 JAG1

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External Reference Information

External Reference

UniProt:P15529 CD46

Gene Names

CD46, MCP, MIC10

Chain

signal peptide:1-34, chain:35-392

Reference Genes

BioGPS Gene:4179 CD46

COSMIC (genes):CD46 CD46

CTD Gene:4179 CD46

dbSNP Gene:4179 CD46

ENSEMBL:ENSG00000117335 CD46

HGNC:6953 CD46

KEGG:hsa:4179 CD46

Monarch:4179 CD46

NCBI Gene:4179 CD46

OMIM:120920 CD46

UCSC:P15529 CD46

Reference Transcript

Participates

as an input of

as a member of

CD46, CR1 [plasma membrane] (Homo sapiens)

as a component of

Inferred To

Homologues of CD46 [plasma membrane] (Gallus gallus)

Cd46 [plasma membrane] (Mus musculus)

Cd46 [plasma membrane] (Rattus norvegicus)

LOC102156626 [plasma membrane] (Canis familiaris)

LOC616002 [plasma membrane] (Bos taurus)

CD46 [plasma membrane] (Gallus gallus)

CD46 [plasma membrane] (Sus scrofa)

Cross References

OpenTargets

ENSG00000117335

ENSEMBL

ENST00000357714, ENSP00000356009, ENSP00000350346, ENST00000367042, ENST00000354848, ENSP00000356008, ENST00000360212, ENST00000322875, ENST00000367041, ENST00000480003, ENST00000367047, ENSP00000353342, ENSP00000350893, ENSP00000356014, ENSP00000346912, ENST00000358170, ENST00000322918, ENSP00000313875, ENSG00000117335, ENSP00000314664, ENSP00000418471

HPA

ENSG00000117335-CD46

GeneCards

CD46

PRO

P15529

Pharos - Targets

P15529

Orphanet

CD46

GlyGen

P15529

PDB

2O39, 8QK3, 1CKL, 5FO8, 3O8E, 3INB, 3L89

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
IntAct:EBI-12735745 C3B			0.761	4
UniProt:P78504 JAG1	2	Ub-JAG1 [plasma membrane] (R-HSA-9013079) JAG1 [plasma membrane] (R-HSA-157098)	0.632	5
UniProt:P01024 C3	20	C3a [extracellular region] (R-HSA-166828) dNQ-C3(672-1663) [extracellular region] (R-HSA-182452) C3 beta chain [extracellular region] (R-HSA-166821) C3b alpha' [extracellular region] (R-HSA-166830) C3 alpha chain [extracellular region] (R-HSA-166820) C3c alpha' chain fragment 2 [plasma membrane] (R-HSA-977594) C3c alpha' chain fragment 1 precursor [plasma membrane] (R-HSA-977595) C3 beta chain [plasma membrane] (R-HSA-977593) C3f [extracellular region] (R-HSA-976779) C3d [plasma membrane] (R-HSA-8853248) C3dg [plasma membrane] (R-HSA-3266505) C3a-desArg [extracellular region] (R-HSA-8852808) C3c alpha' chain fragment 1 [extracellular region] (R-HSA-3266502) C3c alpha' chain fragment 2 [extracellular region] (R-HSA-976818) C3c alpha' chain fragment 1 precursor [extracellular region] (R-HSA-976816) C3 [endoplasmic reticulum lumen] (R-HSA-8956774) p-C3 [endoplasmic reticulum lumen] (R-HSA-8957056) C3 beta chain [secretory granule lumen] (R-HSA-6801014) C3 alpha chain [secretory granule lumen] (R-HSA-6800982) C3 beta chain [azurophil granule lumen] (R-HSA-6799159)	0.623	2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE			0.462	2

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