Based on studies in mouse, the transcription factor SOX10, essential for migration of neural crest cells during formation of the enteric nervous system, directly stimulates CDH19 gene transcription. Cdh19 knockdown results in retarded sacral migration of neural crest cells, while re-expression of Cdh19 partially rescues retarded migration of Sox10-null neural crest cells (Huang et al. 2022). While binding of SOX10 to the CDH19 gene promoter was also demonstrated in mouse melanocytes, Cdh19 was not found to be differentially expressed in melanocytes upon Sox10 gene knockout (Fufa et al. 2015).