Reactome | SRSF12 [nucleoplasm]

SRSF12 [nucleoplasm]

Stable Identifier

R-HSA-9770127

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Serine/arginine-rich splicing factor 12, SRS12_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Homo sapiens)

- Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
  - Formation of pre-mRNPs (Homo sapiens)
    - Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
      - nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF12 [nucleoplasm] (Homo sapiens)
    - capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
      - Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF12 [nucleoplasm] (Homo sapiens)
  - mRNA Splicing (Homo sapiens)
    - mRNA Splicing - Major Pathway (Homo sapiens)
      - Formation of the Spliceosomal A complex (Homo sapiens)
        
        Spliceosomal A complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF12 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal E complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF12 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal B complex (Homo sapiens)
        
        Spliceosomal B complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF12 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF12 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal B* complex (Homo sapiens)
        
        Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF12 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF12 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal Bact complex (Homo sapiens)
        
        Spliceosomal B complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF12 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF12 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal C complex containing intron lariat (Homo sapiens)
        
        Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF12 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal C complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF12 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal C* complex (Homo sapiens)
        
        Spliceosomal C complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF12 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF12 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal E complex (Homo sapiens)
        
        Spliceosomal E complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF12 [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF12 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal P complex and exon ligation (Homo sapiens)
        
        Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF12 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal P complex [nucleoplasm] (Homo sapiens)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF12 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal Pre-B complex (Homo sapiens)
        
        Spliceosomal A complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF12 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF12 [nucleoplasm] (Homo sapiens)
      - Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)
        
        Spliceosomal P complex [nucleoplasm] (Homo sapiens)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF12 [nucleoplasm] (Homo sapiens)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        nonshuttling SRSFs [nucleoplasm] (Homo sapiens)
        
        SRSF12 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8WXF0 SRSF12

Gene Names

SRSF12, SFRS13B, SFRS19, SRRP35

Chain

chain:1-261

Reference Genes

BioGPS Gene:135295 SRSF12

COSMIC (genes):SRSF12 SRSF12

CTD Gene:135295 SRSF12

dbSNP Gene:135295 SRSF12

ENSEMBL:ENSG00000154548 SRSF12

HGNC:21220 SRSF12

KEGG:hsa:135295 SRSF12

Monarch:135295 SRSF12

NCBI Gene:135295 SRSF12

UCSC:Q8WXF0 SRSF12

Reference Transcript

Other Identifiers

11730434_a_at

11730435_at

135295

1552381_PM_at

1552381_at

17021546

230825_PM_at

230825_at

239295_PM_at

239295_at

2964046

2964048

2964050

2964051

2964053

2964054

2964055

2964056

2964057

2964058

2964059

2964060

2964061

2964062

2964063

2964066

2964067

2964068

73962_at

77336_at

8128079

86551_at

A_23_P110903

A_32_P456318

GE572463

GE859905

GO:0000244

GO:0000381

GO:0000395

GO:0000398

GO:0003676

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0006397

GO:0008380

GO:0016071

GO:0016607

GO:0043226

GO:0048025

GO:0050733

GO:0051082

GO:0065003

HMNXSV003005760

HMNXSV003034130

Hs.125958.0.A1_3p_at

Hs.201184.0.A1_3p_at

Hs2.254414.1.S1_3p_s_at

ILMN_1775345

PH_hs_0013406

PH_hs_0037363

TC06001937.hg

Participates

as a member of

nonshuttling SRSFs [nucleoplasm] (Homo sapiens)

Inferred To

SRSF12 [nucleoplasm] (Bos taurus)

SRSF12 [nucleoplasm] (Canis familiaris)

SRSF12 [nucleoplasm] (Gallus gallus)

SRSF12 [nucleoplasm] (Sus scrofa)

srsf10b [nucleoplasm] (Danio rerio)

maca [nucleoplasm] (Drosophila melanogaster)

tcg1 [nucleoplasm] (Schizosaccharomyces pombe)

Srsf12 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

XP_016865781.1, NP_542781.3

ENSEMBL

ENSP00000414302, ENST00000452027, ENSG00000154548

OpenTargets

ENSG00000154548

GeneCards

SRSF12

HPA

ENSG00000154548-SRSF12

PRO

Q8WXF0

Pharos - Targets

Q8WXF0

GlyGen

Q8WXF0

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q86VM9 ZC3H18	1	ZC3H18 [nucleoplasm] (R-HSA-9930040)	0.527	2
UniProt:Q9UGY1 NOL12	1	NOL12 [nucleoplasm] (R-HSA-6791195)	0.527	2

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