S1,S2 Dissociate from S1:ACE2:S2

Stable Identifier
R-HSA-9770063
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
plasma membrane
ReviewStatus
5/5
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S1,S2 Dissociate from S1:ACE2:S2
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After the cleavage of ACE2-bound SARS-CoV-2 Spike into S1 and S2 both fragments dissociate from the S1:ACE2:S2 complex, exposing S2 to host endonucleases. In particular, the Spike RBDs on the S1 fragment trimer can bind to more than one ACE2 molecule which, after cleavage of S, can lead to dissociation of S1:ACE2 from S2, as well as the S1 trimer itself. This process is driven by a change in the RBD conformation from closed to open while bound to ACE2, leaving a trimeric ring of S1 molecules that are attached to the S2 core only through contacts with its two small intermediate subdomains (Benton et al, 2020; reviewed in Rey, 2021).
Literature References
PubMed ID Title Journal Year
34213849 Structure-function relations of the SARS-CoV-2 spike protein and impact of mutations in the variants of concern

Rey, F

C R Biol 2021
32942285 Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion

Benton, DJ, Wrobel, AG, Xu, P, Roustan, C, Martin, SR, Rosenthal, PB, Skehel, JJ, Gamblin, SJ

Nature 2020
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
Mondo
Authored
Stephan, R  (2022-03-23)
Reviewed
Gillespie, ME  (2022-05-10)
Created
Stephan, R  (2022-03-24)
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