Reactome | PRL [extracellular region]

PRL [extracellular region]

Stable Identifier

R-HSA-976984

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Prolactin, PRL_HUMAN

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Growth hormone receptor signaling (Homo sapiens)
    - JAK2 phosphorylation (Homo sapiens)
      - Activated cytokine-like hormone receptors [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
  - Prolactin receptor signaling (Homo sapiens)
    - JAK2 phosphorylation (Homo sapiens)
      - Activated cytokine-like hormone receptors [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - PRLR activation (Homo sapiens)
      - PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - PRLR binds SCF beta-TrCP complex (Homo sapiens)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - PRLR binds SHP2 (PTPN11) (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:SHP2 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - PRLR binds STAT5 (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2:STAT5 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - PRLR is phosphorylated at Ser-349 (Homo sapiens)
      - PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - PRLR-bound STAT5 is phosphorylated (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:p-STAT5 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2:STAT5 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - Prolactin receptor is internalized (Homo sapiens)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer [endosome lumen] (Homo sapiens)
        
        2xp-S349-PRLR:2xJAK2 [endosome lumen] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - Prolactin receptor ligands bind the prolactin receptor (Homo sapiens)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - SH2B binds JAK2 (Homo sapiens)
      - PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - SHP2 is phosphorylated (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:SHP2 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:p-SHP2 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - Tyrosine phosphorylation of PRLR (Homo sapiens)
      - PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Amyloid fiber formation (Homo sapiens)
  - Amyloid fibrils have additional components (Homo sapiens)
    - Amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
      - Localized amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
        
        Prolactin amyloid fibril [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - Amyloid fibrils [plasma membrane] (Homo sapiens)
      - Amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
        
        Localized amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
        
        Prolactin amyloid fibril [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
  - Amyloid precursor proteins form ordered fibrils (Homo sapiens)
    - Amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
      - Localized amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
        
        Prolactin amyloid fibril [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - Amyloid fibril monomers [extracellular region] (Homo sapiens)
      - Localized amyloid fibril monomers [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P01236 PRL

Gene Names

PRL

Chain

signal peptide:1-28, chain:29-227

Reference Genes

BioGPS Gene:5617 PRL

COSMIC (genes):PRL PRL

CTD Gene:5617 PRL

dbSNP Gene:5617 PRL

ENSEMBL:ENSG00000172179.13 PRL

HGNC:9445 PRL

KEGG Gene (Homo sapiens):5617 PRL

Monarch:5617 PRL

NCBI Gene:5617 PRL

OMIM:176760 PRL

Reference Transcript

Other Identifiers

0004670156

11715754_at

17016089

205445_PM_at

205445_at

2945130

2945131

2945132

2945133

2945135

2945136

2945137

2945139

2945140

2945143

2945144

5617

8124185

878_s_at

A_32_P65616

GE59612

GO:0001937

GO:0003674

GO:0005148

GO:0005179

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005768

GO:0006351

GO:0006355

GO:0007165

GO:0007166

GO:0007565

GO:0007595

GO:0008150

GO:0008284

GO:0016525

GO:0022414

GO:0023052

GO:0030879

GO:0031410

GO:0031667

GO:0031904

GO:0031982

GO:0040014

GO:0043226

GO:0046427

GO:0048856

GO:1902895

GO:1903489

HMNXSV003045354

ILMN_1809352

M29386_s_at

PH_hs_0000254

PH_hs_0035318

TC06001320.hg

X00368_xpt2_at

X00540_at

g4506104_3p_at

Participates

as a member of

as a repeated unit of

Prolactin amyloid fibril [extracellular region] (Homo sapiens)

Other forms of this molecule

PRL [endosome lumen]

Inferred To

Prl [extracellular region] (Mus musculus)

Prl [extracellular region] (Rattus norvegicus)

prl.1 [extracellular region] (Xenopus tropicalis)

PRL [extracellular region] (Bos taurus)

PRL [extracellular region] (Canis familiaris)

PRL [extracellular region] (Danio rerio)

PRL [extracellular region] (Gallus gallus)

PRL [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_001157030.1, NP_000939.1

OpenTargets

ENSG00000172179

HPA

ENSG00000172179-PRL

GeneCards

P01236

Ensembl

ENST00000306482, ENSP00000302150, ENSG00000172179

PRO

P01236

Pharos - Targets

P01236

PDB

3D48, 3MZG, 3NCC, 3NPZ, 2Q98, 3N06, 3NCB, 3NCF, 3N0P, 3NCE, 3EW3, 1RW5

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