Reactome | PRL [extracellular region]

PRL

Stable Identifier

R-HSA-976984

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Prolactin, PRL_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Growth hormone receptor signaling (Homo sapiens)
    - JAK2 phosphorylation (Homo sapiens)
      - Activated cytokine-like hormone receptors [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
  - Prolactin receptor signaling (Homo sapiens)
    - JAK2 phosphorylation (Homo sapiens)
      - Activated cytokine-like hormone receptors [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - PRLR activation (Homo sapiens)
      - PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - PRLR binds SCF beta-TrCP complex (Homo sapiens)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - PRLR binds SHP2 (PTPN11) (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:SHP2 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - PRLR binds STAT5 (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2:STAT5 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - PRLR is phosphorylated at Ser-349 (Homo sapiens)
      - PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - PRLR-bound STAT5 is phosphorylated (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:p-STAT5 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2:STAT5 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - Prolactin receptor is internalized (Homo sapiens)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer [endosome lumen] (Homo sapiens)
        
        2xp-S349-PRLR:2xJAK2 [endosome lumen] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - Prolactin receptor ligands bind the prolactin receptor (Homo sapiens)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - SH2B binds JAK2 (Homo sapiens)
      - PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - SHP2 is phosphorylated (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:SHP2 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:p-SHP2 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - Tyrosine phosphorylation of PRLR (Homo sapiens)
      - PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Amyloid fiber formation (Homo sapiens)
  - Amyloid fibrils have additional components (Homo sapiens)
    - Amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
      - Localized amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
        
        Prolactin amyloid fibril [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - Amyloid fibrils [plasma membrane] (Homo sapiens)
      - Amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
        
        Localized amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
        
        Prolactin amyloid fibril [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
  - Amyloid precursor proteins form ordered fibrils (Homo sapiens)
    - Amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
      - Localized amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
        
        Prolactin amyloid fibril [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - Amyloid fibril monomers [extracellular region] (Homo sapiens)
      - Localized amyloid fibril monomers [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P01236 PRL

Gene Names

PRL

Chain

signal peptide:1-28, chain:29-227

Reference Genes

BioGPS Gene:5617 PRL

COSMIC (genes):PRL PRL

CTD Gene:5617 PRL

dbSNP Gene:5617 PRL

ENSEMBL:ENSG00000172179 PRL

HGNC:9445 PRL

KEGG Gene (Homo sapiens):hsa:5617 PRL

Monarch:5617 PRL

NCBI Gene:5617 PRL

OMIM:176760 PRL

Reference Transcript

Other Identifiers

0004670156

11715754_at

17016089

1RW5

205445_at

23353

2945130

2945131

2945132

2945133

2945135

2945136

2945137

2945139

2945140

2945143

2945144

2945145

2945146

2Q98

3D48

3EW3

3MZG

3N06

3N0P

3NCB

3NCC

3NCE

3NCF

3NPZ

42416

5617

62017

8124185

878_s_at

A6XMH3

A_32_P65616

AAA60173

AAB70858

AAH15850

ACT52574

BAA00312

BC015850

CAA23829

CAA25214

CAA38263

CAA38264

CAB023353

CCDS4548

CH471087

D00411

EAW55435

ENSG00000172179

ENSP00000302150

ENST00000306482

EntrezGene:5617

g4506104_3p_at

GE59612

GO:0000003

GO:0001937

GO:0003674

GO:0005148

GO:0005179

GO:0005515

GO:0005575

GO:0005576

GO:0005622

GO:0005623

GO:0005737

GO:0005768

GO:0006810

GO:0007165

GO:0007166

GO:0007565

GO:0007595

GO:0008150

GO:0008283

GO:0009058

GO:0010469

GO:0016525

GO:0031410

GO:0031904

GO:0034641

GO:0040007

GO:0040014

GO:0043226

GO:0044267

GO:0046427

GO:0048646

GO:0048856

GO:0060397

GO:1902895

GQ305133

HGNC:9445

HPA042416

HPA062017

ILMN_1809352

IPR001400

IPR009079

IPR018116

M29386

M29386_s_at

MIM:176760

NM_000948

NM_001163558

NP_000939

NP_001157030

PF00103

PH_hs_0000254

PH_hs_0035318

PR00836

PRL

PRL-201

Q5I0G2

Q5THQ0

TC06001320.hg

U75583

uc003ndp.4

UPI0000001C13

V00566

X00368_xpt2_at

X00540

X00541

X00543

X00544

X54393

Participant Of

hasMember

repeatedUnit

Prolactin amyloid fibril [extracellular region]

Other forms of this molecule

PRL [endosome lumen]

Inferred To

Homologues of PRL [extracellular region] (Bos taurus)

Homologues of PRL [extracellular region] (Canis familiaris)

Homologues of PRL [extracellular region] (Mus musculus)

Homologues of PRL [extracellular region] (Rattus norvegicus)

Homologues of PRL [extracellular region] (Sus scrofa)

PRL [extracellular region] (Bos taurus)

PRL [extracellular region] (Canis familiaris)

PRL [extracellular region] (Danio rerio)

PRL [extracellular region] (Gallus gallus)

PRL [extracellular region] (Mus musculus)

PRL [extracellular region] (Rattus norvegicus)

PRL [extracellular region] (Sus scrofa)

PRL [extracellular region] (Taeniopygia guttata)

PRL [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_001157030.1, NP_000939.1

GeneCards

P01236

DOCK Blaster

3NCC, 3EW3, 3N06, 3NPZ, 2Q98, 3NCE, 3NCF, 3N0P, 3D48, 3MZG, 3NCB

PRO

P01236

PDB

1RW5, 3NPZ, 3NCB, 3N06, 3MZG, 3EW3, 3NCE, 3D48, 2Q98, 3N0P, 3NCC, 3NCF