Reactome | PRL [extracellular region]

PRL [extracellular region]

Stable Identifier

R-HSA-976984

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Prolactin, PRL_HUMAN

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Growth hormone receptor signaling (Homo sapiens)
    - JAK2 phosphorylation (Homo sapiens)
      - Activated cytokine-like hormone receptors [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
  - Prolactin receptor signaling (Homo sapiens)
    - JAK2 phosphorylation (Homo sapiens)
      - Activated cytokine-like hormone receptors [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - PRLR activation (Homo sapiens)
      - PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - PRLR binds SCF beta-TrCP complex (Homo sapiens)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - PRLR binds SHP2 (PTPN11) (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:SHP2 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - PRLR binds STAT5 (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2:STAT5 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - PRLR is phosphorylated at Ser-349 (Homo sapiens)
      - PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - PRLR-bound STAT5 is phosphorylated (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:p-STAT5 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2:STAT5 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - Prolactin receptor is internalized (Homo sapiens)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer [endosome lumen] (Homo sapiens)
        
        2xp-S349-PRLR:2xJAK2 [endosome lumen] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - Prolactin receptor ligands bind the prolactin receptor (Homo sapiens)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - SH2B binds JAK2 (Homo sapiens)
      - PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - SHP2 is phosphorylated (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:SHP2 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:p-SHP2 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - Tyrosine phosphorylation of PRLR (Homo sapiens)
      - PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Amyloid fiber formation (Homo sapiens)
  - Amyloid fibrils have additional components (Homo sapiens)
    - Amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
      - Localized amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
        
        Prolactin amyloid fibril [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - Amyloid fibrils [plasma membrane] (Homo sapiens)
      - Amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
        
        Localized amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
        
        Prolactin amyloid fibril [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
  - Amyloid precursor proteins form ordered fibrils (Homo sapiens)
    - Amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
      - Localized amyloid fibril main peptide chains [extracellular region] (Homo sapiens)
        
        Prolactin amyloid fibril [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)
    - Amyloid fibril monomers [extracellular region] (Homo sapiens)
      - Localized amyloid fibril monomers [extracellular region] (Homo sapiens)
        
        PRL [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P01236 PRL

Gene Names

PRL

Chain

signal peptide:1-28, chain:29-227

Reference Genes

BioGPS Gene:5617 PRL

COSMIC (genes):PRL PRL

CTD Gene:5617 PRL

dbSNP Gene:5617 PRL

ENSEMBL:ENSG00000172179 PRL

HGNC:9445 PRL

KEGG Gene (Homo sapiens):5617 PRL

Monarch:5617 PRL

NCBI Gene:5617 PRL

OMIM:176760 PRL

Reference Transcript

Other Identifiers

0004670156

11715754_at

17016089

1RW5

205445_at

23353

2945130

2945131

2945132

2945133

2945135

2945136

2945137

2945139

2945140

2945143

2945144

2Q98

3D48

3EW3

3MZG

3N06

3N0P

3NCB

3NCC

3NCE

3NCF

3NPZ

42416

5617

62017

8124185

878_s_at

A6XMH3

A_32_P65616

AAA60173

AAB70858

AAH15850

ACT52574

BAA00312

BC015850

CAA23829

CAA25214

CAA38263

CAA38264

CAB023353

CCDS4548

CH471087

D00411

EAW55435

ENSG00000172179

ENSP00000302150

ENST00000306482

ENST00000306482.1

ENST00000617911.4

EntrezGene:5617

EntrezGene:PRL

g4506104_3p_at

GE59612

GO:0000003

GO:0001937

GO:0003674

GO:0005148

GO:0005179

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005737

GO:0005768

GO:0006810

GO:0007165

GO:0007166

GO:0007565

GO:0007595

GO:0008150

GO:0008283

GO:0008284

GO:0009058

GO:0016525

GO:0030879

GO:0031410

GO:0031667

GO:0031904

GO:0034641

GO:0040007

GO:0040014

GO:0043226

GO:0044267

GO:0046427

GO:0048646

GO:0048856

GO:0060397

GO:1902895

GO:1903489

GQ305133

HGNC:9445

HPA042416

HPA062017

ILMN_1809352

IPR001400

IPR009079

IPR018116

M29386

M29386_s_at

MIM:176760

NM_000948

NM_001163558

NP_000939

NP_001157030

PF00103

PH_hs_0000254

PH_hs_0035318

PR00836

PRL

PRL-201

Q5I0G2

Q5THQ0

TC06001320.hg

U75583

UPI0000001C13

V00566

X00368_xpt2_at

X00540

X00540_at

X00541

X00543

X00544

X54393

Participant Of

hasMember

repeatedUnit

Prolactin amyloid fibril [extracellular region]

Other forms of this molecule

PRL [endosome lumen]

Inferred To

PRL [extracellular region] (Bos taurus)

PRL [extracellular region] (Canis familiaris)

PRL [extracellular region] (Danio rerio)

PRL [extracellular region] (Gallus gallus)

PRL [extracellular region] (Mus musculus)

PRL [extracellular region] (Rattus norvegicus)

PRL [extracellular region] (Sus scrofa)

PRL [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_001157030.1, NP_000939.1

OpenTargets

ENSG00000172179

GeneCards

P01236

PRO

P01236

PDB

3N0P, 3D48, 3NCC, 3MZG, 3N06, 3EW3, 3NCE, 2Q98, 1RW5, 3NPZ, 3NCB, 3NCF