miR-224-5p Nonendonucleolytic Minimal RISC [cytosol]

Stable Identifier
R-HSA-9769445
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Synonyms
Argonaute1/3/4: miR-224-5p
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General
The RNA-induced silencing complex contains an Argonaute (AGO) protein, whose PAZ domain binds the 3' end of the miRNA. The PIWI domain of AGO is responsible for cleavage of target RNAs, that is, RNAs complementary to the miRNA. Only AGO2 (EIF2C2) is capable of cleavage, however. AGO1 (EIF2C1), AGO3 (EIF2C3), and AGO4 (EIF2C4) repress translation of target RNAs by binding without cleavage.
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