NPAS4 binds RET gene enhancer

Stable Identifier
R-HSA-9769419
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NPAS4 binds RET gene enhancer
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NPAS4, in complex with ARNT2, binds enhancer elements in the first intron of the RET gene (Sribudiani et al. 2011). In rat primary neurons, both Arnt and Arnt2 were found to bind to the first intron of the Ret gene by high-throughput ChIP-seq (Brigidi et al. 2019).
Literature References
PubMed ID Title Journal Year
20977903 Variants in RET associated with Hirschsprung's disease affect binding of transcription factors and gene expression

Sribudiani, Y, Hofstra, RM, Metzger, M, Osinga, J, Burns, AJ, Rey, A, Thapar, N

Gastroenterology 2011
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Authored
Orlic-Milacic, M  (2022-04-08)
Reviewed
Lin, Y  (2022-07-29)
Created
Orlic-Milacic, M  (2022-03-16)
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