NPAS4 stimulates RET gene expression

Stable Identifier
R-HSA-9769418
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
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NPAS4 stimulates RET gene expression
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NPAS4 directly stimulates RET gene expression (Sribudiani et al. 2011). In rat primary neurons, Ret gene was also found to be significantly upregulated by Npas4 (Brigidi et al. 2019).
Literature References
PubMed ID Title Journal Year
20977903 Variants in RET associated with Hirschsprung's disease affect binding of transcription factors and gene expression

Sribudiani, Y, Hofstra, RM, Metzger, M, Osinga, J, Burns, AJ, Rey, A, Thapar, N

Gastroenterology 2011
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
NPAS4:ARNT2,(NPAS4:ARNT,NPAS4:ARNTL):RET gene [nucleoplasm] (Homo sapiens)
Active Unit
NPAS4:ARNT2,(NPAS4:ARNT,NPAS4:ARNTL) [nucleoplasm]
Authored
Orlic-Milacic, M  (2022-04-08)
Reviewed
Lin, Y  (2022-07-29)
Created
Orlic-Milacic, M  (2022-03-16)
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