NPAS4 binds GEM gene promoter

Stable Identifier
R-HSA-9769011
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NPAS4 binds GEM gene promoter
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Based on a study in rat primary neurons, NPAS4 and its heterodimerization partners ARNT and ARNT2 bind to the GEM gene locus and NPAS4 significantly upregulates GEM gene transcription (Brigidi et al. 2019). In a mouse model system, Gem gene was also identified as an Npas4 target gene which is induced by Npas4 and promotes neuroprotection after ischemic brain injury (Takahashi et al. 2021).
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Npas4 binds Gem gene (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2022-04-08)
Reviewed
Lin, Y  (2022-07-29)
Created
Orlic-Milacic, M  (2022-03-15)
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