Reactome | APOA4(21-94) [extracellular region]

APOA4(21-94) [extracellular region]

Stable Identifier

R-HSA-976882

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Apolipoprotein A-IV amyloid fragment, APOA4, APOA4_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P06727 APOA4

Gene Names

APOA4

Chain

signal peptide:1-20, chain:21-396

Reference Genes

BioGPS Gene:337 APOA4

COSMIC (genes):APOA4 APOA4

CTD Gene:337 APOA4

dbSNP Gene:337 APOA4

ENSEMBL:ENSG00000110244 APOA4

ENSEMBL_homo_sapiens_GENE:ENSG00000110244.7 APOA4

HGNC:602 APOA4

KEGG Gene (Homo sapiens):337 APOA4

Monarch:337 APOA4

NCBI Gene:337 APOA4

OMIM:107690 APOA4

UCSC:P06727 APOA4

Reference Transcript

RefSeq:NM_000482.3 APOA4

Other Identifiers

11758243_s_at

16744717

206894_PM_at

206894_at

337

3392975

3392976

3392977

3392978

3392979

3392980

3392981

3392983

3392984

3392985

34523_at

7951859

8077192

A_23_P87036

A_24_P252934

GO:0002227

GO:0002376

GO:0005215

GO:0005319

GO:0005507

GO:0005515

GO:0005576

GO:0005615

GO:0005768

GO:0005769

GO:0005783

GO:0005788

GO:0005829

GO:0006629

GO:0006869

GO:0006982

GO:0007155

GO:0007159

GO:0008203

GO:0008289

GO:0009986

GO:0010898

GO:0014012

GO:0016042

GO:0016209

GO:0019430

GO:0022600

GO:0030154

GO:0030300

GO:0030312

GO:0031012

GO:0031210

GO:0031410

GO:0032374

GO:0033344

GO:0033700

GO:0034014

GO:0034361

GO:0034364

GO:0034371

GO:0034372

GO:0034375

GO:0034378

GO:0034445

GO:0035634

GO:0042157

GO:0042627

GO:0042632

GO:0042744

GO:0042802

GO:0042803

GO:0043226

GO:0043691

GO:0045202

GO:0045723

GO:0046470

GO:0048856

GO:0051006

GO:0055088

GO:0060228

GO:0061024

GO:0062023

GO:0065003

GO:0065005

GO:0070062

GO:0070328

GO:0072562

GO:0098542

GO:0098754

GO:0098772

GO:0120009

GO:0120020

GO:1905920

HMNXSV003031882

ILMN_1675706

J02758_s_at

PH_hs_0030866

TC11002327.hg

g5174773_3p_at

g5174773_3p_x_at

Participates

as a member of

Systemic amyloid fibril monomers [extracellular region] (Homo sapiens)

as a repeated unit of

Apolipoprotein A-IV fibril [extracellular region] (Homo sapiens)

Other forms of this molecule

APOA4 [early endosome]

APOA4 [cytosol]

APOA4 [endoplasmic reticulum lumen]

APOA4 [extracellular region]

Cross References

RefSeq

NP_000473.2

OpenTargets

ENSG00000110244

GeneCards

P06727

HPA

ENSG00000110244-APOA4

Ensembl

ENSP00000350425, ENST00000357780, ENSG00000110244

PRO

P06727

Pharos - Targets

P06727

HMDB Protein

HMDBP02093

PDB

3S84

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06727 APOA4	5	APOA4 [early endosome] (R-HSA-2429647) APOA4 [cytosol] (R-HSA-2395773) APOA4 [endoplasmic reticulum lumen] (R-HSA-174667) APOA4 [extracellular region] (R-HSA-174701) APOA4(21-94) [extracellular region] (R-HSA-976882)	0.678	10
UniProt:Q96DZ9-2 CMTM5			0.556	3
UniProt:P43360 MAGA6			0.556	3
UniProt:Q9Y371 SHLB1			0.556	3
UniProt:Q8IZR5-2 Q8IZR52			0.556	3
UniProt:Q6RW13-2 AGTRAP			0.556	3
UniProt:P55212 CASP6	5	CASP6 (1-293) [cytosol] (R-HSA-6798132) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128)	0.556	3
UniProt:P20393 NR1D1	1	NR1D1 [nucleoplasm] (R-HSA-375499)	0.518	3