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REST binds promoter and the first intron of NPAS4 gene
Stable Identifier
R-HSA-9768764
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by NPAS4 (Homo sapiens)
Regulation of NPAS4 gene expression (Homo sapiens)
Regulation of NPAS4 gene transcription (Homo sapiens)
REST binds promoter and the first intron of NPAS4 gene (Homo sapiens)
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The transcriptional repressor REST binds the first intron and, to a lesser extent, the promoter regions of the NPAS4 gene in both human kidney cell line HEK293T and mouse embryonic stem cells to repress NPAS4 gene transcription in non-neuronal cells (Bersten et al. 2014).
Literature References
PubMed ID
Title
Journal
Year
24291638
Regulation of the neuronal transcription factor NPAS4 by REST and microRNAs
Whitelaw, ML
,
McCarthy, PJ
,
Bersten, DC
,
Wright, JA
Biochim Biophys Acta
2014
Participants
Input
NPAS4 gene [nucleoplasm]
(Homo sapiens)
REST [nucleoplasm]
(Homo sapiens)
Output
REST:NPAS4 gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Regulation of NPAS4 gene transcription (Homo sapiens)
Authored
Orlic-Milacic, M (2022-04-08)
Reviewed
Lin, Y (2022-07-29)
Created
Orlic-Milacic, M (2022-03-14)
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