NPAS4 gene transcription in non-neuronal cells is repressed by REST

Stable Identifier
R-HSA-9768762
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NPAS4 gene transcription in non-neuronal cells is repressed by REST
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In non-neuronal cells, REST protein represses transcription of the NPAS4 gene (Bersten et al. 2014). In neuronal cells, REST may have a dual effect on NPAS4 expression: acting as a positive regulator of NPAS4 transcription early upon neuronal excitation and as a negative regulator at later time points, allowing NPAS4 to return to basal levels (Prestigio et al. 2021).
Literature References
PubMed ID Title Journal Year
24291638 Regulation of the neuronal transcription factor NPAS4 by REST and microRNAs

Whitelaw, ML, McCarthy, PJ, Bersten, DC, Wright, JA

Biochim Biophys Acta 2014
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
REST:NPAS4 gene [nucleoplasm] (Homo sapiens)
Active Unit
REST [nucleoplasm]
Authored
Orlic-Milacic, M  (2022-04-08)
Reviewed
Lin, Y  (2022-07-29)
Created
Orlic-Milacic, M  (2022-03-14)
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