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CFH [extracellular region]
Stable Identifier
R-HSA-976788
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Complement factor H, CFAH_HUMAN
Locations in the PathwayBrowser for interactor UniProt:P08603 CFH
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Regulation of Complement cascade (Homo sapiens)
Factor H binds host cell surface markers (Homo sapiens)
CFH [extracellular region] (Homo sapiens)
Factor H binds to C3b (Homo sapiens)
CFH [extracellular region] (Homo sapiens)
Factor I inactivates plasma Factor H-bound C3b (Homo sapiens)
CFH [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08603 CFH
Gene Names
CFH, HF, HF1, HF2
Chain
signal peptide:1-18, chain:19-1231
Reference Genes
BioGPS Gene:3075 CFH
COSMIC (genes):CFH CFH
CTD Gene:3075 CFH
dbSNP Gene:3075 CFH
ENSEMBL:ENSG00000000971 CFH
HGNC:4883 CFH
KEGG:hsa:3075 CFH
Monarch:3075 CFH
NCBI Gene:3075 CFH
OMIM:134370 CFH
UCSC:P08603 CFH
Reference Transcript
RefSeq:NM_000186.3 CFH
Participates
as an output of
Factor I inactivates plasma Factor H-bound C3b (Homo sapiens)
as a component of
CFH:C3b [extracellular region] (Homo sapiens)
CFH:Host cell surface [plasma membrane] (Homo sapiens)
as an input of
Factor H binds to C3b (Homo sapiens)
Factor H binds host cell surface markers (Homo sapiens)
as a member of
CFH, CFHR3 [extracellular region] (Homo sapiens)
Inferred To
cfh [extracellular region]
(Danio rerio)
svep1l [extracellular region]
(Xenopus tropicalis)
Homologues of CFH [extracellular region]
(Bos taurus)
Homologues of CFH [extracellular region]
(Danio rerio)
Homologues of CFH [extracellular region]
(Xenopus tropicalis)
f13b [extracellular region]
(Xenopus tropicalis)
LOC100336868 [extracellular region]
(Bos taurus)
cfhl2 [extracellular region]
(Danio rerio)
CFH [extracellular region]
(Bos taurus)
CFH [extracellular region]
(Canis familiaris)
CFH [extracellular region]
(Gallus gallus)
CFH [extracellular region]
(Sus scrofa)
cfhl1 [extracellular region]
(Danio rerio)
Cross References
OpenTargets
ENSG00000000971
ENSEMBL
ENSG00000000971
,
ENSP00000356399
,
ENST00000367429
HPA
ENSG00000000971-CFH
GeneCards
CFH
ZINC - Substances
CFAH_HUMAN
ZINC target
P08603
PRO
P08603
Pharos - Targets
P08603
Orphanet
CFH
PDB
2IC4
,
4J38
,
2BZM
,
3R62
,
4ZH1
,
7ZJM
,
2UWN
,
2XQW
,
5O32
,
6ATG
,
1HFH
,
1HFI
,
4B2R
,
3KXV
,
2G7I
,
2JGW
,
2JGX
,
6ZH1
,
4B2S
,
2KMS
,
1HAQ
,
2QFH
,
3OXU
,
4AYM
,
5O35
,
3GAV
,
2RLP
,
3RJ3
,
3KZJ
,
2RLQ
,
3GAU
,
2QFG
,
3GAW
,
3SW0
,
2V8E
,
4K12
,
2WII
,
5WTB
,
5NBQ
,
1HCC
,
4AYE
,
4AYD
,
4ONT
,
4AYI
,
2W81
,
2W80
,
7WKI
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P02741 CRP
1
CRP(19-224) [extracellular region]
(R-HSA-976719)
0.976
39
IntAct:EBI-12735745 C3B
0.957
13
UniProt:P01024-PRO_0000005911 C3
0.869
10
UniProt:P26022-PRO_0000023545 PTX3
0.756
8
UniProt:P01024 C3
20
C3a [extracellular region]
(R-HSA-166828)
dNQ-C3(672-1663) [extracellular region]
(R-HSA-182452)
C3 beta chain [extracellular region]
(R-HSA-166821)
C3b alpha' [extracellular region]
(R-HSA-166830)
C3 alpha chain [extracellular region]
(R-HSA-166820)
C3c alpha' chain fragment 2 [plasma membrane]
(R-HSA-977594)
C3c alpha' chain fragment 1 precursor [plasma membrane]
(R-HSA-977595)
C3 beta chain [plasma membrane]
(R-HSA-977593)
C3f [extracellular region]
(R-HSA-976779)
C3d [plasma membrane]
(R-HSA-8853248)
C3dg [plasma membrane]
(R-HSA-3266505)
C3a-desArg [extracellular region]
(R-HSA-8852808)
C3c alpha' chain fragment 1 [extracellular region]
(R-HSA-3266502)
C3c alpha' chain fragment 2 [extracellular region]
(R-HSA-976818)
C3c alpha' chain fragment 1 precursor [extracellular region]
(R-HSA-976816)
C3 [endoplasmic reticulum lumen]
(R-HSA-8956774)
p-C3 [endoplasmic reticulum lumen]
(R-HSA-8957056)
C3 beta chain [secretory granule lumen]
(R-HSA-6801014)
C3 alpha chain [secretory granule lumen]
(R-HSA-6800982)
C3 beta chain [azurophil granule lumen]
(R-HSA-6799159)
0.743
6
UniProt:P26022 PTX3
3
PTX3 [specific granule lumen]
(R-HSA-6799620)
PTX3 [extracellular region]
(R-HSA-6806290)
PTX3 [tertiary granule lumen]
(R-HSA-6800932)
0.734
15
UniProt:P05156 CFI
2
CFI(340-583) [extracellular region]
(R-HSA-976750)
CFI(19-335) [extracellular region]
(R-HSA-976782)
0.73
6
UniProt:P08603 CFH
1
CFH [extracellular region]
(R-HSA-976788)
0.713
5
UniProt:A0A024A2C9 A0A024A2C9
0.71
6
ChEBI:28304 HEPARIN
0.702
5
UniProt:P01024-PRO_0000005908 C3
0.676
4
UniProt:P02649 APOE
10
APOE [extracellular region]
(R-HSA-174646)
APOE [endoplasmic reticulum lumen]
(R-HSA-6784908)
p-APOE [endoplasmic reticulum lumen]
(R-HSA-8956980)
APOE [endocytic vesicle lumen]
(R-HSA-3221641)
APOE-4 [extracellular region]
(R-HSA-9711070)
APOE [plasma membrane]
(R-HSA-174615)
APOE [clathrin-coated endocytic vesicle membrane]
(R-HSA-174651)
APOE [endosome membrane]
(R-HSA-174766)
APOE [endosome lumen]
(R-HSA-174804)
APOE [early endosome]
(R-HSA-2429687)
0.672
8
UniProt:P02769 ALB
1
Serum albumin [extracellular region]
(R-BTA-879495)
0.672
10
UniProt:Q932F7 SDRE
0.655
4
UniProt:Q9JXV4 FHBP
0.655
6
UniProt:Q03591 CFHR1
1
CFHR1 [extracellular region]
(R-HSA-8851432)
0.636
3
UniProt:P13605
11
FMOD [lysosomal lumen]
(R-BTA-2105016)
FMOD [lysosomal lumen]
(R-BTA-2046247)
FMOD [extracellular region]
(R-BTA-2046223)
FMOD [Golgi lumen]
(R-BTA-2046229)
FMOD [Golgi lumen]
(R-BTA-2046259)
FMOD [Golgi lumen]
(R-BTA-2046208)
FMOD [Golgi lumen]
(R-BTA-2046308)
FMOD [Golgi lumen]
(R-BTA-2046236)
FMOD [Golgi lumen]
(R-BTA-2046217)
FMOD [Golgi lumen]
(R-BTA-2046193)
FMOD [Golgi lumen]
(R-BTA-2046263)
0.618
4
UniProt:HIB_11110 E1X6C6
0.611
4
phosphocholine [ChEBI:18132]
3
ChoP [extracellular region]
(R-ALL-6814794)
ChoP [endoplasmic reticulum lumen]
(R-ALL-1606280)
ChoP [cytosol]
(R-ALL-194358)
0.609
2
UniProt:P05156-PRO_0000027570 CFI
0.544
2
UniProt:P05156-PRO_0000027569 CFI
0.544
2
ChEBI:39026 LOW-DENSITY LIPOPROTEIN
0.524
5
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