Reactome | CFH [extracellular region]

CFH [extracellular region]

Stable Identifier

R-HSA-976788

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Complement factor H, CFAH_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P08603 CFH

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External Reference Information

External Reference

UniProt:P08603 CFH

Gene Names

CFH, HF, HF1, HF2

Chain

signal peptide:1-18, chain:19-1231

Reference Genes

BioGPS Gene:3075 CFH

COSMIC (genes):CFH CFH

CTD Gene:3075 CFH

dbSNP Gene:3075 CFH

ENSEMBL:ENSG00000000971 CFH

HGNC:4883 CFH

KEGG:hsa:3075 CFH

Monarch:3075 CFH

NCBI Gene:3075 CFH

OMIM:134370 CFH

UCSC:P08603 CFH

Reference Transcript

RefSeq:NM_000186.3 CFH

Participates

as an output of

Factor I inactivates plasma Factor H-bound C3b (Homo sapiens)

as a component of

as an input of

as a member of

CFH, CFHR3 [extracellular region] (Homo sapiens)

Inferred To

cfh [extracellular region] (Danio rerio)

svep1l [extracellular region] (Xenopus tropicalis)

Homologues of CFH [extracellular region] (Bos taurus)

Homologues of CFH [extracellular region] (Danio rerio)

Homologues of CFH [extracellular region] (Xenopus tropicalis)

f13b [extracellular region] (Xenopus tropicalis)

LOC100336868 [extracellular region] (Bos taurus)

cfhl2 [extracellular region] (Danio rerio)

CFH [extracellular region] (Bos taurus)

CFH [extracellular region] (Canis familiaris)

CFH [extracellular region] (Gallus gallus)

CFH [extracellular region] (Sus scrofa)

cfhl1 [extracellular region] (Danio rerio)

Cross References

OpenTargets

ENSG00000000971

ENSEMBL

ENSG00000000971, ENSP00000356399, ENST00000367429

HPA

ENSG00000000971-CFH

GeneCards

CFH

ZINC - Substances

CFAH_HUMAN

ZINC target

P08603

PRO

P08603

Pharos - Targets

P08603

Orphanet

CFH

PDB

2IC4, 4J38, 2BZM, 3R62, 4ZH1, 7ZJM, 2UWN, 2XQW, 5O32, 6ATG, 1HFH, 1HFI, 4B2R, 3KXV, 2G7I, 2JGW, 2JGX, 6ZH1, 4B2S, 2KMS, 1HAQ, 2QFH, 3OXU, 4AYM, 5O35, 3GAV, 2RLP, 3RJ3, 3KZJ, 2RLQ, 3GAU, 2QFG, 3GAW, 3SW0, 2V8E, 4K12, 2WII, 5WTB, 5NBQ, 1HCC, 4AYE, 4AYD, 4ONT, 4AYI, 2W81, 2W80, 7WKI

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02741 CRP	1	CRP(19-224) [extracellular region] (R-HSA-976719)	0.976	39
IntAct:EBI-12735745 C3B			0.957	13
UniProt:P01024-PRO_0000005911 C3			0.869	10
UniProt:P26022-PRO_0000023545 PTX3			0.756	8
UniProt:P01024 C3	20	C3a [extracellular region] (R-HSA-166828) dNQ-C3(672-1663) [extracellular region] (R-HSA-182452) C3 beta chain [extracellular region] (R-HSA-166821) C3b alpha' [extracellular region] (R-HSA-166830) C3 alpha chain [extracellular region] (R-HSA-166820) C3c alpha' chain fragment 2 [plasma membrane] (R-HSA-977594) C3c alpha' chain fragment 1 precursor [plasma membrane] (R-HSA-977595) C3 beta chain [plasma membrane] (R-HSA-977593) C3f [extracellular region] (R-HSA-976779) C3d [plasma membrane] (R-HSA-8853248) C3dg [plasma membrane] (R-HSA-3266505) C3a-desArg [extracellular region] (R-HSA-8852808) C3c alpha' chain fragment 1 [extracellular region] (R-HSA-3266502) C3c alpha' chain fragment 2 [extracellular region] (R-HSA-976818) C3c alpha' chain fragment 1 precursor [extracellular region] (R-HSA-976816) C3 [endoplasmic reticulum lumen] (R-HSA-8956774) p-C3 [endoplasmic reticulum lumen] (R-HSA-8957056) C3 beta chain [secretory granule lumen] (R-HSA-6801014) C3 alpha chain [secretory granule lumen] (R-HSA-6800982) C3 beta chain [azurophil granule lumen] (R-HSA-6799159)	0.743	6
UniProt:P26022 PTX3	3	PTX3 [specific granule lumen] (R-HSA-6799620) PTX3 [extracellular region] (R-HSA-6806290) PTX3 [tertiary granule lumen] (R-HSA-6800932)	0.734	15
UniProt:P05156 CFI	2	CFI(340-583) [extracellular region] (R-HSA-976750) CFI(19-335) [extracellular region] (R-HSA-976782)	0.73	6
UniProt:P08603 CFH	1	CFH [extracellular region] (R-HSA-976788)	0.713	5
UniProt:A0A024A2C9 A0A024A2C9			0.71	6
ChEBI:28304 HEPARIN			0.702	5
UniProt:P01024-PRO_0000005908 C3			0.676	4
UniProt:P02649 APOE	10	APOE [extracellular region] (R-HSA-174646) APOE [endoplasmic reticulum lumen] (R-HSA-6784908) p-APOE [endoplasmic reticulum lumen] (R-HSA-8956980) APOE [endocytic vesicle lumen] (R-HSA-3221641) APOE-4 [extracellular region] (R-HSA-9711070) APOE [plasma membrane] (R-HSA-174615) APOE [clathrin-coated endocytic vesicle membrane] (R-HSA-174651) APOE [endosome membrane] (R-HSA-174766) APOE [endosome lumen] (R-HSA-174804) APOE [early endosome] (R-HSA-2429687)	0.672	8
UniProt:P02769 ALB	1	Serum albumin [extracellular region] (R-BTA-879495)	0.672	10
UniProt:Q932F7 SDRE			0.655	4
UniProt:Q9JXV4 FHBP			0.655	6
UniProt:Q03591 CFHR1	1	CFHR1 [extracellular region] (R-HSA-8851432)	0.636	3
UniProt:P13605	11	FMOD [lysosomal lumen] (R-BTA-2105016) FMOD [lysosomal lumen] (R-BTA-2046247) FMOD [extracellular region] (R-BTA-2046223) FMOD [Golgi lumen] (R-BTA-2046229) FMOD [Golgi lumen] (R-BTA-2046259) FMOD [Golgi lumen] (R-BTA-2046208) FMOD [Golgi lumen] (R-BTA-2046308) FMOD [Golgi lumen] (R-BTA-2046236) FMOD [Golgi lumen] (R-BTA-2046217) FMOD [Golgi lumen] (R-BTA-2046193) FMOD [Golgi lumen] (R-BTA-2046263)	0.618	4
UniProt:HIB_11110 E1X6C6			0.611	4
phosphocholine [ChEBI:18132]	3	ChoP [extracellular region] (R-ALL-6814794) ChoP [endoplasmic reticulum lumen] (R-ALL-1606280) ChoP [cytosol] (R-ALL-194358)	0.609	2
UniProt:P05156-PRO_0000027570 CFI			0.544	2
UniProt:P05156-PRO_0000027569 CFI			0.544	2
ChEBI:39026 LOW-DENSITY LIPOPROTEIN			0.524	5