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CFH [extracellular region]
Stable Identifier
R-HSA-976788
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Complement factor H, CFAH_HUMAN
Locations in the PathwayBrowser for interactor UniProt:P08603 CFH
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Regulation of Complement cascade (Homo sapiens)
Factor H binds host cell surface markers (Homo sapiens)
CFH [extracellular region] (Homo sapiens)
Factor H binds to C3b (Homo sapiens)
CFH [extracellular region] (Homo sapiens)
Factor I inactivates plasma Factor H-bound C3b (Homo sapiens)
CFH [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08603 CFH
Gene Names
CFH, HF, HF1, HF2
Chain
signal peptide:1-18, chain:19-1231
Reference Genes
BioGPS Gene:3075 CFH
COSMIC (genes):CFH CFH
CTD Gene:3075 CFH
dbSNP Gene:3075 CFH
ENSEMBL:ENSG00000000971 CFH
HGNC:4883 CFH
KEGG Gene (Homo sapiens):3075 CFH
Monarch:3075 CFH
NCBI Gene:3075 CFH
OMIM:134370 CFH
UCSC:P08603 CFH
Reference Transcript
RefSeq:NM_000186.3 CFH
Other Identifiers
0002970373
11743846_s_at
11743847_x_at
11757990_s_at
16675398
215388_s_at
2373337
2373338
2373340
2373342
2373344
2373345
2373347
2373349
2373352
2373353
2373354
2373371
2373372
2373373
2373377
2373378
2373379
2373381
2373382
2373383
2373384
2373385
2373388
2373389
2373391
2373392
2373394
2373396
2373397
2373398
2373399
2373400
2373435
2373437
2373438
2373439
2373445
3075
32249_at
7908459
A_14_P102601
A_23_P114740
A_24_P273972
A_33_P3318288
A_33_P3367692
GE61567
GO:0002376
GO:0003674
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0006950
GO:0006956
GO:0006957
GO:0008150
GO:0008201
GO:0016032
GO:0030449
GO:0042802
GO:0043167
GO:0043226
GO:0043395
GO:0044403
GO:0045087
GO:0070062
GO:0072562
GO:1903659
HMNXSV003016459
HMNXSV003042195
Hs.296941.0.S1_3p_s_at
ILMN_1698144
ILMN_1810910
ILMN_2412192
M65292_s_at
PH_hs_0014288
TC01006291.hg
Participates
as an output of
Factor I inactivates plasma Factor H-bound C3b (Homo sapiens)
as a component of
CFH:C3b [extracellular region] (Homo sapiens)
CFH:Host cell surface [plasma membrane] (Homo sapiens)
as an input of
Factor H binds to C3b (Homo sapiens)
Factor H binds host cell surface markers (Homo sapiens)
as a member of
CFH, CFHR3 [extracellular region] (Homo sapiens)
Inferred To
cfh [extracellular region]
(Danio rerio)
cfh [extracellular region]
(Xenopus tropicalis)
svep1l [extracellular region]
(Xenopus tropicalis)
Homologues of CFH [extracellular region]
(Danio rerio)
Homologues of CFH [extracellular region]
(Xenopus tropicalis)
f13b [extracellular region]
(Danio rerio)
Cfh [extracellular region]
(Mus musculus)
Cfh [extracellular region]
(Rattus norvegicus)
LOC100336868 [extracellular region]
(Bos taurus)
cfhl2 [extracellular region]
(Danio rerio)
cfhl5 [extracellular region]
(Danio rerio)
CFH [extracellular region]
(Canis familiaris)
CFH [extracellular region]
(Gallus gallus)
CFH [extracellular region]
(Sus scrofa)
CFH [extracellular region]
(Xenopus tropicalis)
cfhl1 [extracellular region]
(Danio rerio)
cfhl3 [extracellular region]
(Danio rerio)
cfhl4 [extracellular region]
(Danio rerio)
Cross References
RefSeq
NP_000177.2
OpenTargets
ENSG00000000971
GeneCards
P08603
HPA
ENSG00000000971-CFH
ZINC target
P08603
Ensembl
ENSP00000356399
,
ENSG00000000971
,
ENST00000367429
PRO
P08603
Pharos - Targets
P08603
Orphanet
15437
GlyGen
P08603
PDB
4AYE
,
2G7I
,
6ATG
,
2RLP
,
4B2R
,
3SW0
,
3KZJ
,
3GAU
,
1FHC
,
1HCC
,
1HFI
,
2W81
,
1HAQ
,
4B2S
,
4ONT
,
2XQW
,
4ZH1
,
2RLQ
,
4AYI
,
3GAV
,
5O35
,
2QFG
,
2JGW
,
3RJ3
,
4AYM
,
3GAW
,
3OXU
,
5NBQ
,
2JGX
,
2BZM
,
2KMS
,
2IC4
,
4AYD
,
5O32
,
2QFH
,
3R62
,
4J38
,
5WTB
,
2WII
,
2V8E
,
1HFH
,
4K12
,
3KXV
,
2UWN
,
1KOV
,
2W80
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P02741 CRP
1
CRP(19-224) [extracellular region]
(R-HSA-976719)
0.976
39
IntAct:EBI-12735745 C3B
0.957
13
UniProt:P01024-PRO_0000005911 C3
0.869
10
UniProt:P26022-PRO_0000023545 PTX3
0.756
8
UniProt:P01024 C3
20
C3 beta chain [extracellular region]
(R-HSA-166821)
C3a-desArg [extracellular region]
(R-HSA-8852808)
C3 alpha chain [extracellular region]
(R-HSA-166820)
C3 [endoplasmic reticulum lumen]
(R-HSA-8956774)
C3 alpha chain [secretory granule lumen]
(R-HSA-6800982)
C3c alpha' chain fragment 1 precursor [extracellular region]
(R-HSA-976816)
C3 alpha chain [azurophil granule lumen]
(R-HSA-6799161)
C3c alpha' chain fragment 2 [extracellular region]
(R-HSA-976818)
C3 beta chain [plasma membrane]
(R-HSA-977593)
C3d [plasma membrane]
(R-HSA-8853248)
C3c alpha' chain fragment 2 [plasma membrane]
(R-HSA-977594)
C3f [extracellular region]
(R-HSA-976779)
C3 beta chain [secretory granule lumen]
(R-HSA-6801014)
C3dg [plasma membrane]
(R-HSA-3266505)
C3c alpha' chain fragment 1 [extracellular region]
(R-HSA-3266502)
C3b alpha' [extracellular region]
(R-HSA-166830)
C3d fragment [extracellular region]
(R-HSA-198999)
C3 beta chain [azurophil granule lumen]
(R-HSA-6799159)
C3c alpha' chain fragment 1 precursor [plasma membrane]
(R-HSA-977595)
p-C3 [endoplasmic reticulum lumen]
(R-HSA-8957056)
0.743
6
UniProt:P26022 PTX3
3
PTX3 [specific granule lumen]
(R-HSA-6799620)
PTX3 [tertiary granule lumen]
(R-HSA-6800932)
PTX3 [extracellular region]
(R-HSA-6806290)
0.734
15
UniProt:P05156 CFI
2
CFI(340-583) [extracellular region]
(R-HSA-976750)
CFI(19-335) [extracellular region]
(R-HSA-976782)
0.73
6
UniProt:P08603 CFH
1
CFH [extracellular region]
(R-HSA-976788)
0.713
5
UniProt:A0A024A2C9 A0A024A2C9
0.71
6
ChEBI:28304 HEPARIN
0.702
5
UniProt:P01024-PRO_0000005908 C3
0.676
4
UniProt:P02649 APOE
10
APOE [extracellular region]
(R-HSA-174646)
p-APOE [endoplasmic reticulum lumen]
(R-HSA-8956980)
APOE-4 [extracellular region]
(R-HSA-9711070)
APOE [clathrin-coated endocytic vesicle membrane]
(R-HSA-174651)
APOE [endosome membrane]
(R-HSA-174766)
APOE [plasma membrane]
(R-HSA-174615)
APOE [early endosome]
(R-HSA-2429687)
APOE [endosome lumen]
(R-HSA-174804)
APOE [endoplasmic reticulum lumen]
(R-HSA-6784908)
APOE [endocytic vesicle lumen]
(R-HSA-3221641)
0.672
8
UniProt:P02769 ALB
1
Serum albumin [extracellular region]
(R-BTA-879495)
0.672
10
UniProt:Q9JXV4 Q9JXV4
0.655
6
UniProt:Q932F7 SDRE
0.655
4
UniProt:Q03591 CFHR1
1
CFHR1 [extracellular region]
(R-HSA-8851432)
0.636
3
UniProt:P13605
11
FMOD [lysosomal lumen]
(R-BTA-2046247)
FMOD [lysosomal lumen]
(R-BTA-2105016)
FMOD [Golgi lumen]
(R-BTA-2046217)
FMOD [Golgi lumen]
(R-BTA-2046259)
FMOD [Golgi lumen]
(R-BTA-2046208)
FMOD [Golgi lumen]
(R-BTA-2046229)
FMOD [Golgi lumen]
(R-BTA-2046263)
FMOD [Golgi lumen]
(R-BTA-2046236)
FMOD [Golgi lumen]
(R-BTA-2046308)
FMOD [extracellular region]
(R-BTA-2046223)
FMOD [Golgi lumen]
(R-BTA-2046193)
0.618
4
UniProt:HIB_11110 E1X6C6
0.611
4
phosphocholine [ChEBI:18132]
5
ChoP [lysosomal lumen]
(R-ALL-1605750)
ChoP [extracellular region]
(R-ALL-6814794)
ChoP [plasma membrane]
(R-ALL-1610735)
ChoP [cytosol]
(R-ALL-194358)
ChoP [endoplasmic reticulum lumen]
(R-ALL-1606280)
0.609
2
UniProt:P05156-PRO_0000027569 CFI
0.544
2
UniProt:P05156-PRO_0000027570 CFI
0.544
2
ChEBI:39026 LOW-DENSITY LIPOPROTEIN
0.524
5
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