Factor I inactivates plasma Factor H-bound C3b

Stable Identifier
R-HSA-976743
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
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Factor I inactivates plasma Factor H-bound C3b
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Complement factor I (CFI) cleaves the alpha chain of C3b at two positions, generating inactivated C3b (iC3b) and a small fragment C3f, which is released. The majority of the alpha chain is retained as two fragments which are tethered by disulphide bonds. iC3b is proteolytically inactive.

Literature References
PubMed ID Title Journal Year
6219696 Kinetic and thermodynamic analysis of the control of C3b by the complement regulatory proteins factors H and I

Pangburn, MK, Muller-Eberhard, HJ

Biochemistry 1983
Participants
Input
Output
Participates
as an event of
Catalyst Activity

serine-type endopeptidase activity of CFI:CFH:C3b [extracellular region]

Physical Entity
CFI:CFH:C3b [extracellular region] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
Factor I inactivates plasma Factor H-bound C3b (Bos taurus)
Factor I inactivates plasma Factor H-bound C3b (Canis familiaris)
Factor I inactivates plasma Factor H-bound C3b (Danio rerio)
Factor I inactivates plasma Factor H-bound C3b (Gallus gallus)
Factor I inactivates plasma Factor H-bound C3b (Mus musculus)
Factor I inactivates plasma Factor H-bound C3b (Rattus norvegicus)
Factor I inactivates plasma Factor H-bound C3b (Sus scrofa)
Factor I inactivates plasma Factor H-bound C3b (Xenopus tropicalis)
Authored
Jupe, S  (2010-10-26)
Reviewed
Fraczek, LA  (2012-02-13)
Bradley, DT  (2012-02-13)
Created
Jupe, S  (2010-10-13)
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