Factor I inactivates plasma Factor H-bound C3b

Stable Identifier
R-HSA-976743
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
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Factor I inactivates plasma Factor H-bound C3b
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Complement factor I (CFI) cleaves the alpha chain of C3b at two positions, generating inactivated C3b (iC3b) and a small fragment C3f, which is released. The majority of the alpha chain is retained as two fragments which are tethered by disulphide bonds. iC3b is proteolytically inactive.

Literature References
PubMed ID Title Journal Year
6219696 Kinetic and thermodynamic analysis of the control of C3b by the complement regulatory proteins factors H and I

Pangburn, MK, Muller-Eberhard, HJ

Biochemistry 1983
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of CFI:CFH:C3b [extracellular region]
Physical Entity
CFI:CFH:C3b [extracellular region]
Activity
serine-type endopeptidase activity (0004252)
Orthologous Events
Factor I inactivates plasma Factor H-bound C3b (Danio rerio)
Factor I inactivates plasma Factor H-bound C3b (Gallus gallus)
Authored
Jupe, S  (2010-10-26)
Reviewed
Bradley, DT  (2012-02-13)
Fraczek, LA  (2012-02-13)
Created
Jupe, S  (2010-10-13)
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