Amyloid fibrils have additional components

Stable Identifier
R-HSA-976734
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Amyloid fibrils have additional components
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In addition to the main fibril peptide, mature amyloid fibrils have additional components. Serum amyloid P component (SAP) binds to all types of amyloid fibrils and is a universal constituent of amyloid deposits. SAP binding protects amyloid fibrils from proteolytic degradation (Tennent et al. 1995, Westermark 2005). SAP may function as a chaperone for amyloid formation (Coker et al. 2000).

Glycosaminoglycans (GAGs) and proteoglycans are found associated with all types of amyloid deposits (Alexandrescu 2005). Of the different types of GAG heparan sulfate and dermatan sulfate are the most prominent in amyloid deposits (Hirschfield & Hawkins, 2003). GAGs have been implicated in the nucleation of fibrils, they can also stabilize mature fibrils against dissociation (Yamaguchi et al. 2003) and proteolytic degradation (Gupta-Bansal et al. 1995).

Perlecan coimmunolocalizes with all types of amyloids (Snow & Wright 1989), accelerating fibril formation (Castillo et al. 1998), stabilizing them once formed (Castillo et al. 1997), and protecting them from proteolytic degradation (Gupta-Bansal et al. 1995).

APOE isoform 4 binds tightly to soluble ABeta peptide forming complexes that resist dissociation; it also binds to ABeta in its fibril form (Bales et al. 2002).
Literature References
PubMed ID Title Journal Year
10583407 Interactions of Alzheimer amyloid-beta peptides with glycosaminoglycans effects on fibril nucleation and growth

Deng, J, McLaurin, J, Franklin, T, Fraser, PE, Zhang, X

Eur J Biochem 1999
20807650 Heparan sulfate proteoglycans in amyloidosis

Li, JP, Zhang, X

Prog Mol Biol Transl Sci 2010
2409350 Temporal relationship between glycosaminoglycan accumulation and amyloid deposition during experimental amyloidosis. A histochemical study

Kisilevsky, R, Snow, AD

Lab Invest 1985
Amyloid P component. A critical review

Hutchinson, WL, Pepys, MB, Collins, PM, Hohenester, E, Gallimore, J, Booth, DR

Amyloid 1997
118839 Binding of serum amyloid P-component (SAP) by amyloid fibrils

Skinner, M, Pepys, MB, Dyck, RF, Cohen, AS, de Beer, FC

Clin Exp Immunol 1979
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
Amyloidosis DOID:9120
Authored
Jupe, S  (2010-10-15)
Reviewed
Perry, G  (2011-04-08)
Perry, G  (2015-11-09)
Created
Jupe, S  (2010-10-13)
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