Reactome | MAP1LC3B binds KEAP1 and SQSTM1

MAP1LC3B binds KEAP1 and SQSTM1

Stable Identifier

R-HSA-9766677

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SQSTM1 targets ubiquitinated cargo such as KEAP1 for degradation through the selective autophagy pathway. In addition to binding to the KEAP1, SQSTM1 also interacts with LC3 proteins that coat the forming autophagosome (Bjorkoy et al, 2005; Lee et al, 2017; Jain et al, 2010; reviewed in Jiang et al, 2015). Interaction between SQSTM1, ubiquitinated KEAP1 and LC3 proteins is enhanced through the binding of SESN1 and SESN2 proteins (Bae et al, 2013; Ro et al, 2014).

Literature References

PubMed ID	Title	Journal	Year
25040165	Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1 Lee, JH, Semple, IA, Ro, SH, Park, H, Park, H, Kim, M, Park, HW, Kim, JS	FEBS J	2014
23274085	Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage Lim, JM, Park, YN, Lee, HE, Sung, SH, Bae, SH, Kang, D, Oh, SY, Lee, SK, Rhee, SG	Cell Metab	2013
26117325	p62 links autophagy and Nrf2 signaling Rojo de la Vega, M, Zhang, DD, Chapman, E, Harder, B, Wong, PK, Jiang, T	Free Radic Biol Med	2015
28380357	Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination Weihl, CC, Chou, TF, Razani, B, Pittman, SK, Lee, Y, Keith, AL	Cell Rep	2017
16286508	p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death Lamark, T, Overvatn, A, Brech, A, Johansen, T, Perander, M, Bjørkøy, G, Stenmark, H, Outzen, H	J Cell Biol	2005