Reactome | CUL3:RBX1 ubiquitinates KEAP1

CUL3:RBX1 ubiquitinates KEAP1

Stable Identifier

R-HSA-9766645

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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KEAP1 is ubiquitinated by the CUL3:RBX1 complex in an SQSTM1-dependent manner (Zhang et al, 2005). Ubiquitination of KEAP1 renders it a substrate for SQSTM1-dependent degradation through the selective autophagy pathway (Zhang et al, 2005; Taguchi et al, 2012).

Literature References

PubMed ID	Title	Journal	Year
15983046	Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway Zhang, DD, Lo, SC, Sun, Z, Habib, GM, Lieberman, MW, Hannink, M	J Biol Chem	2005
22872865	Keap1 degradation by autophagy for the maintenance of redox homeostasis Taguchi, K, Fujikawa, N, Komatsu, M, Ishii, T, Unno, M, Akaike, T, Motohashi, H, Yamamoto, M	Proc Natl Acad Sci U S A	2012