PRMT1 binds type I PRMT inhibitors

Stable Identifier
R-HSA-9766608
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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PRMT1 binds type I PRMT inhibitors
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Type I protein arginine methyltransferases (PRMTs) catalyze mono- and asymmetric dimethylation of arginine residues. In humans there are five enzymes of this type: PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8. MS023 is a selective inhibitor of type I PRMTs. It inhibits PRMT1 with an IC50 of 30 +- 9 nM (Eram et al, 2015).
Literature References
PubMed ID Title Journal Year
26598975 A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases

Vedadi, M, Li, F, Barsyte-Lovejoy, D, Szewczyk, M, Brown, PJ, Liu, J, Jin, J, Wu, H, Arrowsmith, CH, Senisterra, G, Kaniskan, HÜ, Dong, A, Shen, Y, Eram, MS, Zeng, H, Schapira, M, Butler, KV, Speed, BA, Dela Seña, C

ACS Chem Biol 2016
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Authored
Stephan, R  (2022-02-23)
Created
Stephan, R  (2022-02-23)
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