PRMT1 binds type I PRMT inhibitors

Stable Identifier
R-HSA-9766608
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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PRMT1 binds type I PRMT inhibitors
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Type I protein arginine methyltransferases (PRMTs) catalyze mono- and asymmetric dimethylation of arginine residues. In humans there are five enzymes of this type: PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8. MS023 is a selective inhibitor of type I PRMTs. It inhibits PRMT1 with an IC50 of 30 +- 9 nM (Eram et al, 2015).
Literature References
PubMed ID Title Journal Year
26598975 A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases

Eram, MS, Shen, Y, Szewczyk, M, Wu, H, Senisterra, G, Li, F, Butler, KV, Kaniskan, HÜ, Speed, BA, Dela Seña, C, Dong, A, Zeng, H, Schapira, M, Brown, PJ, Arrowsmith, CH, Barsyte-Lovejoy, D, Liu, J, Vedadi, M, Jin, J

ACS Chem Biol 2016
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Authored
Stephan, R  (2022-02-23)
Created
Stephan, R  (2022-02-23)
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