Impaired BRCA2 binding to SEM1 (DSS1)

Stable Identifier
R-HSA-9763198
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Impaired BRCA2 binding to SEM1 (DSS1)
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This pathway describes BRCA2 cancer mutations that affect the ability of BRCA2 to bind to SEM1 (DSS1), a small protein of 70 amino acids that regulates BRCA2 stability and its nuclear localization (reviewed in Le et al. 2021).
Literature References
PubMed ID Title Journal Year
34440403 Guardians of the Genome: BRCA2 and Its Partners

Heyer, WD, Le, HP, Liu, J

Genes (Basel) 2021
Participants
Events
Participates
as an event of
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Orlic-Milacic, M  (2022-01-26)
Reviewed
Liu, J  (2022-01-26)
Le, HP  (2022-01-26)
Heyer, WD  (2022-01-26)
Created
Orlic-Milacic, M  (2022-01-31)
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