PREDN:ALB dissociates

Stable Identifier
R-HSA-9762345
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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PREDN:ALB dissociates
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Binding of prednisone (PREDN) to albumin (ALB) is high-capacity but weak affinity. This means the PREDN:ALB complex is on average short-lived and soon dissociates (Pugeat et al, 1981; Boudinot and Jusko, 1984).
Literature References
PubMed ID Title Journal Year
6492791 Plasma protein binding interaction of prednisone and prednisolone

Boudinot, FD, Jusko, WJ

J Steroid Biochem 1984
7195405 Transport of steroid hormones: interaction of 70 drugs with testosterone-binding globulin and corticosteroid-binding globulin in human plasma

Nisula, BC, Pugeat, MM, Dunn, JF

J Clin Endocrinol Metab 1981
Participants
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Output
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Orthologous Events
PREDN:ALB dissociates (Bos taurus)
PREDN:ALB dissociates (Canis familiaris)
PREDN:ALB dissociates (Gallus gallus)
PREDN:ALB dissociates (Mus musculus)
PREDN:ALB dissociates (Rattus norvegicus)
PREDN:ALB dissociates (Sus scrofa)
PREDN:ALB dissociates (Xenopus tropicalis)
Authored
Stephan, R  (2022-01-20)
Reviewed
Thorn, CF  (2022-08-05)
Created
Stephan, R  (2022-01-20)
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