PREDL:ALB dissociates

Stable Identifier
R-HSA-9762343
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Binding of prednisolone (PREDL) to albumin (ALB) is high-capacity but weak affinity. This means the PREDL:ALB complex is on average short-lived and soon dissociates (Pugeat et al, 1981; Boudinot and Jusko, 1984).
Literature References
PubMed ID Title Journal Year
6492791 Plasma protein binding interaction of prednisone and prednisolone

Boudinot, FD, Jusko, WJ

J Steroid Biochem 1984
7195405 Transport of steroid hormones: interaction of 70 drugs with testosterone-binding globulin and corticosteroid-binding globulin in human plasma

Nisula, BC, Pugeat, MM, Dunn, JF

J Clin Endocrinol Metab 1981
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