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PREDL:ALB dissociates
Stable Identifier
R-HSA-9762343
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Drug ADME (Homo sapiens)
Prednisone ADME (Homo sapiens)
PREDL:ALB dissociates (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Binding of prednisolone (PREDL) to albumin (ALB) is high-capacity but weak affinity. This means the PREDL:ALB complex is on average short-lived and soon dissociates (Pugeat et al, 1981; Boudinot and Jusko, 1984).
Literature References
PubMed ID
Title
Journal
Year
6492791
Plasma protein binding interaction of prednisone and prednisolone
Boudinot, FD
,
Jusko, WJ
J Steroid Biochem
1984
7195405
Transport of steroid hormones: interaction of 70 drugs with testosterone-binding globulin and corticosteroid-binding globulin in human plasma
Nisula, BC
,
Pugeat, MM
,
Dunn, JF
J Clin Endocrinol Metab
1981
Participants
Input
PREDL:ALB [extracellular region]
(Homo sapiens)
Output
ALB [extracellular region]
(Homo sapiens)
PREDL [extracellular region]
Participates
as an event of
Prednisone ADME (Homo sapiens)
Orthologous Events
PREDL:ALB dissociates (Bos taurus)
PREDL:ALB dissociates (Canis familiaris)
PREDL:ALB dissociates (Gallus gallus)
PREDL:ALB dissociates (Mus musculus)
PREDL:ALB dissociates (Rattus norvegicus)
PREDL:ALB dissociates (Sus scrofa)
PREDL:ALB dissociates (Xenopus tropicalis)
Authored
Stephan, R (2022-03-02)
Reviewed
Thorn, CF (2022-08-05)
Created
Stephan, R (2022-01-20)
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