Reactome | NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1

NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1

Stable Identifier

R-HSA-9762091

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Homo sapiens)

General

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NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1

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GSK3-dependent phosphorylation of NFE2L2 promotes its subsequent ubiquitination by a BTRC:CUL1 E3 ligase complex (Salazar et al, 2006; Rada et al, 2011; Rada et al, 2012; Rojo et al, 2012; reviewed in Baird and Yamamoto, 2020; Yamamoto et al, 2018).

Literature References

PubMed ID	Title	Journal	Year
29717933	The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis Motohashi, H, Yamamoto, M, Kensler, TW	Physiol Rev	2018
21245377	SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner Cuadrado, A, Chowdhry, S, Rojo, AI, Rada, P, Hayes, JD, McMahon, M	Mol Cell Biol	2011
32284348	The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway Yamamoto, M, Baird, L	Mol Cell Biol	2020
22751928	Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis Rada, P, Garcia-Mayoral, MF, Cotte, A, Innamorato, NG, Van Leuven, F, Cuadrado, A, Devijver, H, Rojo, AI, Evrard-Todeschi, N, Hayes, JD, Tobón-Velasco, JC, Jaworski, T, Bertho, G	Mol Cell Biol	2012
16551619	Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2 de Sagarra, RM, Velasco, D, Cuadrado, A, Salazar, M, Rojo, AI	J Biol Chem	2006
22142471	Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3 Cuadrado, A, Medina-Campos, ON, Pedraza-Chaverri, J, Rojo, AI, Rada, P, Zúñiga-Toalá, A, Espada, S, López-Gazcón, A	Free Radic Biol Med	2012