HBV X protein binds SQSTM1 oligomer

Stable Identifier
R-HSA-9761900
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Hepatitis B virus
Compartment
cytosol
ReviewStatus
5/5
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HBV X protein binds SQSTM1 oligomer
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Chronic hepatitis B virus (HBV) infection stimulates expression of glucose-6-phosphate dehydrogenase (G6PD), the enzyme that catalyzes the first step of the pentose phosphate pathway (PPP). HBV-stimulated G6PD expression depends upon activation of the NFE2L2 pathway through sequestration of the KEAP1 negative regulator of NFE2L2. HBV X protein interacts with SQSTM1, also known as p62, and stimulates formation of an X:SQSTM1:KEAP1 complex. This complex disrupts the KEAP1-dependent ubiquitination of NFE2L2, stabilizing the transcription factor and allowing it to translocate to the nucleus to stimulate expression of target genes including G6PD (Liu et al, 2017; reviewed in Baird and Yamamoto, 2020; Bender and Hildt, 2019).
Literature References
PubMed ID Title Journal Year
31546975 Effect of Hepatitis Viruses on the Nrf2/Keap1-Signaling Pathway and Its Impact on Viral Replication and Pathogenesis

Bender, D, Hildt, E

Int J Mol Sci 2019
32284348 The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

Yamamoto, M, Baird, L

Mol Cell Biol 2020
26583321 Hepatitis B virus stimulates G6PD expression through HBx-mediated Nrf2 activation

Cui, D, Zhou, T, Liu, W, Xu, X, Jia, S, He, Z, Lin, X, Fang, M, Liu, B

Cell Death Dis 2015
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
hepatitis B DOID:2043 Serum hepatitis
Authored
Rothfels, K  (2021-10-08)
Reviewed
Cuadrado, A  (2022-02-23)
Created
Rothfels, K  (2022-01-16)
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