NFE2L2-dependent IDH1 gene expression

Stable Identifier
R-HSA-9761844
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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NFE2L2-dependent IDH1 gene expression
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The IDH1 gene encodes the cytosolic NADP-dependent isocitrate dehydrogenase, which catalyzes the reversible conversion of isocitrate to 2-oxoglutarate, generating NADPH. IDH1 is thus a key player in maintaining the redox and metabolic balance in the cell and has been shown to be dysregulated in many cancers (reviewed in Mondesir et al, 2016; Chang et al, 2019). IDH1 expression is regulated downstream of the KEAP1-NFE2L2 pathway and has been shown to be a direct target of NFE2L2 (Mitsuishi et al, 2012; reviewed in Baird and Yamamoto, 2020; Hayes et al, 2020).
Literature References
PubMed ID Title Journal Year
31221981 The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism

Chang, S, Yim, S, Park, H

Exp Mol Med 2019
32649885 Oxidative Stress in Cancer

Hayes, JD, Dinkova-Kostova, AT, Tew, KD

Cancer Cell 2020
32284348 The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

Baird, L, Yamamoto, M

Mol Cell Biol 2020
27621679 IDH1 and IDH2 mutations as novel therapeutic targets: current perspectives

Mondesir, J, Willekens, C, Touat, M, de Botton, S

J Blood Med 2016
22789539 Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming

Mitsuishi, Y, Taguchi, K, Kawatani, Y, Shibata, T, Nukiwa, T, Aburatani, H, Yamamoto, M, Motohashi, H

Cancer Cell 2012
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
IDH1 gene:p-NFE2L2 [nucleoplasm] (Homo sapiens)
Active Unit
p-NFE2L2 [nucleoplasm]
Authored
Rothfels, K  (2021-10-08)
Reviewed
Cuadrado, A  (2022-02-23)
Created
Rothfels, K  (2022-01-15)
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