NFE2L2-dependent IDH1 gene expression

Stable Identifier
R-HSA-9761844
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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The IDH1 gene encodes the cytosolic NADP-dependent isocitrate dehydrogenase, which catalyzes the reversible conversion of isocitrate to 2-oxoglutarate, generating NADPH. IDH1 is thus a key player in maintaining the redox and metabolic balance in the cell and has been shown to be dysregulated in many cancers (reviewed in Mondesir et al, 2016; Chang et al, 2019). IDH1 expression is regulated downstream of the KEAP1-NFE2L2 pathway and has been shown to be a direct target of NFE2L2 (Mitsuishi et al, 2012; reviewed in Baird and Yamamoto, 2020; Hayes et al, 2020).
Literature References
PubMed ID Title Journal Year
31221981 The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism

Park, H, Yim, S, Chang, S

Exp Mol Med 2019
32649885 Oxidative Stress in Cancer

Hayes, JD, Tew, KD, Dinkova-Kostova, AT

Cancer Cell 2020
32284348 The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

Yamamoto, M, Baird, L

Mol Cell Biol 2020
27621679 IDH1 and IDH2 mutations as novel therapeutic targets: current perspectives

Mondesir, J, Touat, M, de Botton, S, Willekens, C

J Blood Med 2016
22789539 Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming

Motohashi, H, Yamamoto, M, Nukiwa, T, Aburatani, H, Kawatani, Y, Shibata, T, Mitsuishi, Y, Taguchi, K

Cancer Cell 2012
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