NFE2L2-dependent GSR gene expression

Stable Identifier
R-HSA-9761843
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NFE2L2-dependent GSR gene expression
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Glutathione reductase (GSR) contributes to the redox balance in a cell by catalyzing the reduction of glutathione disulphide (GSSG) to glutathione (GSH). Expression of GSR is regulated in part by the KEAP1:NFE2L2 pathway through anti-oxidant response elements (AREs) in the promoter (Harvey et al, 2009; Thimmulappa et al, 2002; reviewed in Baird and Yamamoto, 2020).
Literature References
PubMed ID Title Journal Year
12234984 Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray

Yamamoto, M, Srisuma, S, Mai, KH, Biswal, S, Thimmulappa, RK, Kensler, TW

Cancer Res 2002
32284348 The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

Yamamoto, M, Baird, L

Mol Cell Biol 2020
19028565 Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

Myers, A, Fujii, J, Blake, DJ, Biswal, S, Thimmulappa, RK, Singh, A, Harvey, CJ, Wakabayashi, N, Ling, G

Free Radic Biol Med 2009
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
GSR gene:p-NFE2L2 [nucleoplasm] (Homo sapiens)
Active Unit
p-NFE2L2 [nucleoplasm]
Authored
Rothfels, K  (2021-10-08)
Reviewed
Cuadrado, A  (2022-02-23)
Created
Rothfels, K  (2022-01-15)
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