NFE2L2 binds the TALDO1 gene

Stable Identifier
R-HSA-9761830
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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The TALDO1 gene encodes transaldolase, a dimeric enzyme that catalyzes reactions in the non-oxidative branch of the pentose phosphate pathway (PPP) and generates NADPH (reviewed in Ge et al, 2020; Smolkova et al, 2020). TALDO1 gene expression is regulated downstream of the KEAP1-NFE2L2 pathway and contributes to maintenance of redox balance and metabolic reprogramming in response to numerous oxidative and metabolic stressors. NFE2L2 binds to the anti-oxidant response element (ARE) in the TALDO1 promoter as assessed by ChIP-seq (Mitsuishi et al, 2012; reviewed in Baird and Yamamoto, 2020).
Literature References
PubMed ID Title Journal Year
32284348 The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

Yamamoto, M, Baird, L

Mol Cell Biol 2020
22789539 Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming

Motohashi, H, Yamamoto, M, Nukiwa, T, Aburatani, H, Kawatani, Y, Shibata, T, Mitsuishi, Y, Taguchi, K

Cancer Cell 2012
31989830 Nuclear Factor Erythroid 2-Related Factor 2 in Regulating Cancer Metabolism

Leguina-Ruzzi, A, Bai, P, Smolková, K, Kovács, T, Sipos, A, Mikó, E

Antioxid Redox Signal 2020
32582032 The Role of the Pentose Phosphate Pathway in Diabetes and Cancer

Ge, T, Yang, J, Tong, X, Wang, Y, Zhou, S, Li, Y

Front Endocrinol (Lausanne) 2020
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