NFE2L2 binds the ME1 gene

Stable Identifier
R-HSA-9761825
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NFE2L2 binds the ME1 gene
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ME1 encodes the cytosolic NADP-dependent malic enzyme, which converts malate to pyruvate, generating NADPH. Through the generation of NADPH, ME1 contributes to the redox balance of the cell as well as playing a key role in lipid and cholesterol biosynthesis. ME1 links the citric acid cycle and glycolysis through the interconversion of pyruvate and malate and also play a role in the Warburg effect (reviewed in Simmen et al, 2020).
ME1 has been shown to be a NFE2L2-responsive gene (Thimmulappa et al, 2002; Wu et al, 2011) and NFE2L2 binds directly to the anti-oxidant response element (ARE) in the ME1 promoter as assessed by ChIP-seq (Mitsuishi et al, 2012; reviewed in Baird and Yamamoto, 2020; Smolkova et al, 2020; Ge et al, 2020)
Literature References
PubMed ID Title Journal Year
12234984 Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray

Yamamoto, M, Srisuma, S, Mai, KH, Biswal, S, Thimmulappa, RK, Kensler, TW

Cancer Res 2002
21775727 Beneficial role of Nrf2 in regulating NADPH generation and consumption

Klaassen, CD, Wu, KC, Cui, JY

Toxicol Sci 2011
32284348 The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

Yamamoto, M, Baird, L

Mol Cell Biol 2020
22789539 Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming

Motohashi, H, Yamamoto, M, Nukiwa, T, Aburatani, H, Kawatani, Y, Shibata, T, Mitsuishi, Y, Taguchi, K

Cancer Cell 2012
33064660 Malic enzyme 1 (ME1) in the biology of cancer: it is not just intermediary metabolism

Simmen, RCM, Alhallak, I, Simmen, FA

J Mol Endocrinol 2020
31989830 Nuclear Factor Erythroid 2-Related Factor 2 in Regulating Cancer Metabolism

Leguina-Ruzzi, A, Bai, P, Smolková, K, Kovács, T, Sipos, A, Mikó, E

Antioxid Redox Signal 2020
32582032 The Role of the Pentose Phosphate Pathway in Diabetes and Cancer

Ge, T, Yang, J, Tong, X, Wang, Y, Zhou, S, Li, Y

Front Endocrinol (Lausanne) 2020
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Authored
Rothfels, K  (2021-10-08)
Reviewed
Cuadrado, A  (2022-02-23)
Created
Rothfels, K  (2022-01-15)
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