IDH1 encodes the cytosolic NADP-dependent isocitrate dehydrogenase, which catalyzes the reversible conversion of isocitrate to 2-oxoglutarate, generating NADPH (reviewed in Mondesir et al, 2016). Through its role in generating NADPH as well as carbon intermediates of the citric acid cycle, IDH1 contributes to the maintenance of cellular redox balance and flux through metabolic pathways, including during oncogenesis (reviewed in Mondesir et al, 2016; Chang et al, 2019). IDH1 has been shown to be a direct target of NFE2L2, a key regulator of the antioxidant response pathway. NFE2L2 binds to the anti-oxidant response element (ARE) in the IDH1 promoter as assessed by ChIP-seq to promote NFE2L2-dependent expression (Mitsuishi et al, 2012; Thimmulappa et al, 2002; Wu et al, 2011; reviewed in Baird and Yamamoto, 2020; Hayes et al, 2020).
de Botton, S,