NFE2L2 binds the IDH1 gene

Stable Identifier
Reaction [binding]
Homo sapiens
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IDH1 encodes the cytosolic NADP-dependent isocitrate dehydrogenase, which catalyzes the reversible conversion of isocitrate to 2-oxoglutarate, generating NADPH (reviewed in Mondesir et al, 2016). Through its role in generating NADPH as well as carbon intermediates of the citric acid cycle, IDH1 contributes to the maintenance of cellular redox balance and flux through metabolic pathways, including during oncogenesis (reviewed in Mondesir et al, 2016; Chang et al, 2019). IDH1 has been shown to be a direct target of NFE2L2, a key regulator of the antioxidant response pathway. NFE2L2 binds to the anti-oxidant response element (ARE) in the IDH1 promoter as assessed by ChIP-seq to promote NFE2L2-dependent expression (Mitsuishi et al, 2012; Thimmulappa et al, 2002; Wu et al, 2011; reviewed in Baird and Yamamoto, 2020; Hayes et al, 2020).
Literature References
PubMed ID Title Journal Year
12234984 Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray

Yamamoto, M, Srisuma, S, Mai, KH, Biswal, S, Thimmulappa, RK, Kensler, TW

Cancer Res 2002
31221981 The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism

Park, H, Yim, S, Chang, S

Exp Mol Med 2019
21775727 Beneficial role of Nrf2 in regulating NADPH generation and consumption

Klaassen, CD, Wu, KC, Cui, JY

Toxicol Sci 2011
32649885 Oxidative Stress in Cancer

Hayes, JD, Tew, KD, Dinkova-Kostova, AT

Cancer Cell 2020
32284348 The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

Yamamoto, M, Baird, L

Mol Cell Biol 2020
27621679 IDH1 and IDH2 mutations as novel therapeutic targets: current perspectives

Mondesir, J, Touat, M, de Botton, S, Willekens, C

J Blood Med 2016
22789539 Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming

Motohashi, H, Yamamoto, M, Nukiwa, T, Aburatani, H, Kawatani, Y, Shibata, T, Mitsuishi, Y, Taguchi, K

Cancer Cell 2012
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