NFE2L2 binds the GSR gene

Stable Identifier
R-HSA-9761818
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NFE2L2 binds the GSR gene
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GSR encodes glutathione reductase, an enzyme involved in maintaining the redox balance in the cell by catalyzing the reduction of glutathione disulphide (GSSG) to glutathione (GSH). Expression of GSR is regulated in part by the KEAP1-NFE2L2 pathway, and NFE2L2 binds to the anti-oxidant response (ARE) elements in the GSR promoter as demonstrated by chromatin immunoprecipitation (ChIP) studies in mouse (Harvey et al, 2009; Thimmulappa et al, 2002; reviewed in Baird and Yamamoto, 2020).
Literature References
PubMed ID Title Journal Year
12234984 Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray

Thimmulappa, RK, Mai, KH, Srisuma, S, Kensler, TW, Yamamoto, M, Biswal, S

Cancer Res 2002
32284348 The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

Baird, L, Yamamoto, M

Mol Cell Biol 2020
19028565 Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

Harvey, CJ, Thimmulappa, RK, Singh, A, Blake, DJ, Ling, G, Wakabayashi, N, Fujii, J, Myers, A, Biswal, S

Free Radic Biol Med 2009
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Authored
Rothfels, K  (2021-10-08)
Reviewed
Cuadrado, A  (2022-02-23)
Created
Rothfels, K  (2022-01-15)
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