AcK- NFE2L2, MAFG and CREBBP, EP300 bind the G6PD

Stable Identifier
Reaction [binding]
Homo sapiens
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Cytosolic glucose-6-phosphate dehydrogenase (G6PD) catalyzes the reaction of glucose 6-phosphate and NADP+ to form D-glucono-1,5-lactone 6-phosphate and NADPH + H+. This constitutes the first committed step of the pentose phosphate pathway and it is critical to the maintenance of NAPDH pool and redox homeostasis (reviewed in Hayes et al, 2020; Ge et al, 2020; Lin et al, 2016; Harris and DeNicola, 2020). G6PD expression is regulated downstream of the KEAP1-NFE2L2 pathway (Wu et al, 2011; Thimmulappa et al, 2002; reviewed in Baird and Yamamoto, 2020). Expression is mediated by the binding of the NFE2L2:MAFG heterodimer to the anti-oxidant response element in the G6PD promoter. CREBBP is likewise recruited upon stimulation with the NFE2L2-inducer diethyl malate (DEM), and DEM treatment increases the accumulation of histone modifications associated with a transcriptionally active state (Hirotsu et al, 2012; Mitsuishi et al, 2012; Tang et al, 2021; reviewed in Hayes et al, 2020).
Literature References
PubMed ID Title Journal Year
12234984 Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray

Yamamoto, M, Srisuma, S, Mai, KH, Biswal, S, Thimmulappa, RK, Kensler, TW

Cancer Res 2002
21775727 Beneficial role of Nrf2 in regulating NADPH generation and consumption

Klaassen, CD, Wu, KC, Cui, JY

Toxicol Sci 2011
32649885 Oxidative Stress in Cancer

Hayes, JD, Tew, KD, Dinkova-Kostova, AT

Cancer Cell 2020
33859744 c-MYC-directed NRF2 drives malignant progression of head and neck cancer via glucose-6-phosphate dehydrogenase and transketolase activation

Chu, PY, Chen, HH, Lin, LM, Chang, JY, Lin, SF, Chen, YT, Liu, KJ, Huang, YW, Chuang, YJ, Kuo, CC, Tsai, FY, Fang, HL, Hsiao, JR, Jiang, SS, Tang, YC

Theranostics 2021
32303435 The Complex Interplay between Antioxidants and ROS in Cancer

DeNicola, GM, Harris, IS

Trends Cell Biol 2020
22965115 Nrf2-MafG heterodimers contribute globally to antioxidant and metabolic networks

Nagashima, T, Yamamoto, M, Hirotsu, Y, Engel, JD, Funayama, R, Katsuoka, F, Nakayama, K, Nishida, Y

Nucleic Acids Res 2012
22789539 Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming

Motohashi, H, Yamamoto, M, Nukiwa, T, Aburatani, H, Kawatani, Y, Shibata, T, Mitsuishi, Y, Taguchi, K

Cancer Cell 2012
32582032 The Role of the Pentose Phosphate Pathway in Diabetes and Cancer

Ge, T, Yang, J, Tong, X, Wang, Y, Zhou, S, Li, Y

Front Endocrinol (Lausanne) 2020
  A Master Regulator of Oxidative Stress - The Transcription Factor Nrf2

DeNicola, GM, Lin, T-Y, Cantley, LC

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