Expression of PAX8 in intermediate mesoderm

Stable Identifier
R-HSA-9761173
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of PAX8 in intermediate mesoderm
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
PAX8 is expressed first in the intermediate mesoderm and continuously in the developing excretory system (inferred from the mouse homolog). Retinoic acid activates expression of Pax8 in the mouse embryo (Cartry et al. 2006). While Pax8 mutant mice show no urogenital abnormalities, Pax8 Pax2 double mutants fail to form the metanephros, ureter, and genital tracts (Bouchard et al. 2002).
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
atRA [extracellular region]
Inferred From
Expression of Pax8 in intermediate mesoderm (Mus musculus)
Authored
May, B  (2022-01-10)
Reviewed
Tam, PPL  (2023-05-03)
Created
May, B  (2022-01-11)
Cite Us!