AcK-NFE2L2 binds the GCLM gene

Stable Identifier
Reaction [binding]
Homo sapiens
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Phosphorylated, acetylated NFE2L2 binds to the antioxidant response element in the promoter of the GCLM gene as assessed by chromatin immunoprecipitation. Acetylation of NFE2L2 increases, but is not essential for, NFE2L2 DNA binding and transcription factor activity at the GCLM promoter (Sun et al, 2009). The GCLM gene encodes the regulatory subunit of glutamate-cysteine ligase, an enzyme responsible for one step in the synthesis of glutathione (reviewed in Lu, 2013). GCLM expression is downstream of the KEAP1-NFE2L2 pathway (Sekhat et al, 2000; McMahon et al, 2001; Thimmulappa et al, 2002; reviewed in Baird and Yamamoto, 2020; Lu, 2013).
Literature References
PubMed ID Title Journal Year
12234984 Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray

Yamamoto, M, Srisuma, S, Mai, KH, Biswal, S, Thimmulappa, RK, Kensler, TW

Cancer Res 2002
11309284 The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes

Cavin, C, Wolf, CR, Chanas, SA, McMahon, M, McLellan, LI, Henderson, CJ, Yamamoto, M, Hayes, JD, Itoh, K

Cancer Res 2001
22995213 Glutathione synthesis

Lu, SC

Biochim Biophys Acta 2013
10733945 Inhibition of the 26S proteasome induces expression of GLCLC, the catalytic subunit for gamma-glutamylcysteine synthetase

Freeman, ML, Xu, ZQ, Soltaninassab, SR, Sekhar, KR, Domann, FE, Meredith, MJ, Borrelli, MJ

Biochem Biophys Res Commun 2000
32284348 The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

Yamamoto, M, Baird, L

Mol Cell Biol 2020
19273602 Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response

Sun, Z, Zhang, DD, Chin, YE

Mol Cell Biol 2009
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