Phosphorylated, acetylated NFE2L2 binds to the antioxidant response element in the promoter of the GCLM gene as assessed by chromatin immunoprecipitation. Acetylation of NFE2L2 increases, but is not essential for, NFE2L2 DNA binding and transcription factor activity at the GCLM promoter (Sun et al, 2009). The GCLM gene encodes the regulatory subunit of glutamate-cysteine ligase, an enzyme responsible for one step in the synthesis of glutathione (reviewed in Lu, 2013). GCLM expression is downstream of the KEAP1-NFE2L2 pathway (Sekhat et al, 2000; McMahon et al, 2001; Thimmulappa et al, 2002; reviewed in Baird and Yamamoto, 2020; Lu, 2013).
Yamamoto, M, Srisuma, S, Mai, KH, Biswal, S, Thimmulappa, RK, Kensler, TW
Cavin, C, Wolf, CR, Chanas, SA, McMahon, M, McLellan, LI, Henderson, CJ, Yamamoto, M, Hayes, JD, Itoh, K
Lu, SC
Freeman, ML, Xu, ZQ, Soltaninassab, SR, Sekhar, KR, Domann, FE, Meredith, MJ, Borrelli, MJ
Yamamoto, M, Baird, L
Sun, Z, Zhang, DD, Chin, YE
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