The GCLC gene encodes the catalytic heavy chain subunit of glutamine cysteine ligase. This enzyme contributes to the antioxidant response by synthesizing glutathione from glutamate and cysteine, and is a target gene of the KEAP1:NFE2L2 pathway (Sekhar et al, 2000; McMahon et al, 2001; Thimmulappa et al, 2002). Acetylation of NFE2L2 by CREBBP or EP300 increases the DNA-binding and transcription factor binding activity of NFE2L2 at the GCLC promoter (Sun et al, 2009).
Yamamoto, M, Srisuma, S, Mai, KH, Biswal, S, Thimmulappa, RK, Kensler, TW
Cavin, C, Wolf, CR, Chanas, SA, McMahon, M, McLellan, LI, Henderson, CJ, Yamamoto, M, Hayes, JD, Itoh, K
Freeman, ML, Xu, ZQ, Soltaninassab, SR, Sekhar, KR, Domann, FE, Meredith, MJ, Borrelli, MJ
Sun, Z, Zhang, DD, Chin, YE
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