AcK-NFE2L2 binds the GCLC gene

Stable Identifier
Reaction [binding]
Homo sapiens
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The GCLC gene encodes the catalytic heavy chain subunit of glutamine cysteine ligase. This enzyme contributes to the antioxidant response by synthesizing glutathione from glutamate and cysteine, and is a target gene of the KEAP1:NFE2L2 pathway (Sekhar et al, 2000; McMahon et al, 2001; Thimmulappa et al, 2002). Acetylation of NFE2L2 by CREBBP or EP300 increases the DNA-binding and transcription factor binding activity of NFE2L2 at the GCLC promoter (Sun et al, 2009).
Literature References
PubMed ID Title Journal Year
12234984 Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray

Yamamoto, M, Srisuma, S, Mai, KH, Biswal, S, Thimmulappa, RK, Kensler, TW

Cancer Res 2002
11309284 The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes

Cavin, C, Wolf, CR, Chanas, SA, McMahon, M, McLellan, LI, Henderson, CJ, Yamamoto, M, Hayes, JD, Itoh, K

Cancer Res 2001
10733945 Inhibition of the 26S proteasome induces expression of GLCLC, the catalytic subunit for gamma-glutamylcysteine synthetase

Freeman, ML, Xu, ZQ, Soltaninassab, SR, Sekhar, KR, Domann, FE, Meredith, MJ, Borrelli, MJ

Biochem Biophys Res Commun 2000
19273602 Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response

Sun, Z, Zhang, DD, Chin, YE

Mol Cell Biol 2009
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