NFE2L2 binds CREBBP,EP300

Stable Identifier
R-HSA-9760082
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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NFE2L2 binds CREBBP,EP300
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NFE2L2 binds to CREBBP (also known as CBP, Creb-binding partner) and EP300 (p300) as assessed by co-immunoprecipitation and pulldown experiments. The interaction is mediated by the Neh5 domain of NFE2L2 and the C-terminal residues 1725-2414 of EP300. Both EP300 and CREBBP are able to acetylate NFE2L2 in vitro and in vivo leading to enhanced DNA-binding and transcriptional activation at some but not all NFE2L2-dependent promoters (Sun et al, 2009).
Literature References
PubMed ID Title Journal Year
19273602 Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response

Sun, Z, Zhang, DD, Chin, YE

Mol Cell Biol 2009
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Orthologous Events
NFE2L2 binds CREBBP,EP300 (Bos taurus)
NFE2L2 binds CREBBP,EP300 (Caenorhabditis elegans)
NFE2L2 binds CREBBP,EP300 (Canis familiaris)
NFE2L2 binds CREBBP,EP300 (Drosophila melanogaster)
NFE2L2 binds CREBBP,EP300 (Gallus gallus)
NFE2L2 binds CREBBP,EP300 (Mus musculus)
NFE2L2 binds CREBBP,EP300 (Rattus norvegicus)
NFE2L2 binds CREBBP,EP300 (Sus scrofa)
NFE2L2 binds CREBBP,EP300 (Xenopus tropicalis)
Authored
Rothfels, K  (2021-10-08)
Reviewed
Cuadrado, A  (2022-02-23)
Created
Rothfels, K  (2021-12-14)
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