Expression of GATA4 in lateral plate mesoderm

Stable Identifier
R-HSA-9759859
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Expression of GATA4 in lateral plate mesoderm
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The GATA4 gene is transcribed to yield mRNA and the mRNA is transcribed to yield GATA4 protein. FOXF1 binds enhancers of the GATA4 gene and activates transcription of GATA4 (inferred from mouse homologs). BMP4 is also required to activate GATA4 in the embryo (inferred from mouse homologs). BMP4 activates FOXF1 and may act on GATA4 via FOXF1.
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
BMP4 dimer [extracellular region] (Homo sapiens)
Regulator
FOXF1:GATA4 gene [nucleoplasm] (Homo sapiens)
Active Unit
FOXF1 [nucleoplasm]
Inferred From
Expression of Gata4 in lateral plate mesoderm (Mus musculus)
Authored
May, B  (2021-12-14)
Reviewed
Mosimann, C  (2022-11-09)
Prummel, KD  (2022-11-09)
Created
May, B  (2021-12-14)
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