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DTL [nucleoplasm]
Stable Identifier
R-HSA-975985
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Denticleless protein homolog, DTL_HUMAN, CDT2
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Damage Bypass (Homo sapiens)
Recognition of DNA damage by PCNA-containing replication complex (Homo sapiens)
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
DTL [nucleoplasm] (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
DTL [nucleoplasm] (Homo sapiens)
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
DTL [nucleoplasm] (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
DTL [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
DTL [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
DTL [nucleoplasm] (Homo sapiens)
CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Homo sapiens)
CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
DTL [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
DTL [nucleoplasm] (Homo sapiens)
COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Homo sapiens)
CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
DTL [nucleoplasm] (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
DTL [nucleoplasm] (Homo sapiens)
COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
DTL [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ligase complex [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
DTL [nucleoplasm] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
DTL [nucleoplasm] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
DCAF protein [nucleoplasm] (Homo sapiens)
DTL [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NZJ0 DTL
Gene Names
DTL, CDT2, CDW1, DCAF2, L2DTL, RAMP
Chain
chain:1-730
Reference Genes
BioGPS Gene:51514 DTL
COSMIC (genes):DTL DTL
CTD Gene:51514 DTL
dbSNP Gene:51514 DTL
ENSEMBL:ENSG00000143476 DTL
HGNC:30288 DTL
KEGG Gene (Homo sapiens):51514 DTL
Monarch:51514 DTL
NCBI Gene:51514 DTL
OMIM:610617 DTL
UCSC:Q9NZJ0 DTL
Reference Transcript
RefSeq:NM_016448.3 DTL
RefSeq:NM_001286229.1 DTL
Other Identifiers
0003850136
11726302_a_at
11758499_s_at
16677201
218585_PM_s_at
218585_s_at
222680_PM_s_at
222680_s_at
2378938
2378939
2378943
2378944
2378945
2378946
2378952
2378953
2378954
2378955
2378956
2378957
2378959
2378961
2378963
2378968
2378969
2378970
2378971
47338_at
50890_at
51514
76439_at
7909568
A_14_P108506
A_14_P118274
A_14_P139799
A_23_P10385
GE58734
GO:0000209
GO:0000278
GO:0003674
GO:0004842
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005635
GO:0005654
GO:0005694
GO:0005730
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0006259
GO:0006260
GO:0006464
GO:0006511
GO:0006513
GO:0006950
GO:0006974
GO:0007049
GO:0007095
GO:0007165
GO:0008150
GO:0009056
GO:0009058
GO:0009411
GO:0010971
GO:0016020
GO:0016567
GO:0019985
GO:0030674
GO:0031464
GO:0031465
GO:0031965
GO:0032991
GO:0034641
GO:0043161
GO:0043226
GO:0045732
GO:0048511
GO:0051726
GO:0080008
HMNXSV003009109
Hs.126774.0.S1_3p_a_at
ILMN_1745251
ILMN_1779711
PH_hs_0007225
TC01001767.hg
g7705575_3p_a_at
Participates
as a member of
DCAF protein [nucleoplasm] (Homo sapiens)
as a component of
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
Inferred To
Dtl [nucleoplasm]
(Mus musculus)
Dtl [nucleoplasm]
(Rattus norvegicus)
l(2)dtl [nucleoplasm]
(Drosophila melanogaster)
cdt-2 [nucleoplasm]
(Caenorhabditis elegans)
dtl [nucleoplasm]
(Danio rerio)
dtl [nucleoplasm]
(Xenopus tropicalis)
DTL [nucleoplasm]
(Bos taurus)
DTL [nucleoplasm]
(Canis familiaris)
DTL [nucleoplasm]
(Gallus gallus)
DTL [nucleoplasm]
(Sus scrofa)
cdt2 [nucleoplasm]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_001273158.1
,
NP_057532.3
OpenTargets
ENSG00000143476
GeneCards
Q9NZJ0
HPA
ENSG00000143476-DTL
Ensembl
ENSP00000355958
,
ENST00000366991
,
ENSG00000143476
PRO
Q9NZJ0
Pharos - Targets
Q9NZJ0
PDB
6QC0
HMDB Protein
HMDBP14567
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