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VPRBP [cytosol]
Stable Identifier
R-HSA-975984
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
DCAF1, Protein VPRBP, VPRBP_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
VPRBP [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
VPRBP [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
VPRBP [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
VPRBP [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
VPRBP [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
VPRBP [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
VPRBP [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
VPRBP [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
VPRBP [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
VPRBP [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y4B6 VPRBP
Gene Names
VPRBP, DCAF1, KIAA0800, RIP
Chain
chain:1-1507
Reference Genes
BioGPS Gene:9730 VPRBP
CTD Gene:9730 VPRBP
dbSNP Gene:9730 VPRBP
ENSEMBL:ENSG00000145041 VPRBP
ENSEMBL_homo_sapiens_GENE:ENSG00000145041.17 VPRBP
HGNC:30911 VPRBP
KEGG Gene (Homo sapiens):9730 VPRBP
Monarch:9730 VPRBP
NCBI Gene:9730 VPRBP
UCSC:Q9Y4B6 VPRBP
Reference Transcript
RefSeq:XM_011534277.2 VPRBP
RefSeq:XM_011534276.2 VPRBP
RefSeq:XM_005276753.4 VPRBP
RefSeq:NM_014703.2 VPRBP
RefSeq:XM_017007550.1 VPRBP
RefSeq:XM_017007549.1 VPRBP
RefSeq:XM_011534275.2 VPRBP
RefSeq:NM_001171904.1 VPRBP
RefSeq:XM_011534274.2 VPRBP
RefSeq:XM_017007548.1 VPRBP
RefSeq:XM_017007547.1 VPRBP
RefSeq:XM_011534273.2 VPRBP
RefSeq:XM_005276755.4 VPRBP
RefSeq:XM_017007546.1 VPRBP
Other Identifiers
11756398_a_at
11762378_a_at
16954576
204376_PM_at
204376_at
204377_PM_s_at
204377_s_at
226476_PM_s_at
226476_s_at
226477_PM_at
226477_at
226481_PM_at
226481_at
2675629
2675630
2675631
2675632
2675633
2675634
2675635
2675636
2675637
2675638
2675639
2675640
2675641
2675642
2675643
2675644
2675645
2675647
2675649
2675650
2675652
2675653
2675654
2675655
2675656
2675657
2675659
2675660
2675661
2675662
2675663
2675664
2675665
2675666
2675668
2675669
38873_at
53184_at
8087748
9730
A_23_P212595
A_24_P26170
A_24_P26177
GE81953
GO:0000122
GO:0000166
GO:0001650
GO:0002376
GO:0003824
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0006310
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0008180
GO:0016301
GO:0016310
GO:0016567
GO:0016740
GO:0030154
GO:0030163
GO:0030183
GO:0030331
GO:0033151
GO:0035212
GO:0036211
GO:0043226
GO:0043687
GO:0045732
GO:0048856
GO:0060090
GO:0080008
GO:0106310
GO:0140096
GO:1990244
GO:1990756
HMNXSV003003531
HMNXSV003007831
HMNXSV003020685
Hs.118738.2.A1_3p_a_at
Hs.118738.2.A2_3p_at
ILMN_2181089
PH_hs_0039428
TC03001436.hg
g7662315_3p_a_at
Participates
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
VPRBP [cytosol]
(Gallus gallus)
VPRBP [cytosol]
(Sus scrofa)
mahj [cytosol]
(Drosophila melanogaster)
DCAF1 [cytosol]
(Bos taurus)
DCAF1 [cytosol]
(Canis familiaris)
Dcaf1 [cytosol]
(Mus musculus)
Dcaf1 [cytosol]
(Rattus norvegicus)
dcaf1 [cytosol]
(Xenopus tropicalis)
dcaf-1 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
XP_016863035.1
,
XP_005276810.1
,
XP_011532576.1
,
XP_016863039.1
,
XP_011532575.1
,
XP_016863036.1
,
NP_055518.1
,
XP_005276812.1
,
XP_011532578.1
,
XP_016863037.1
,
NP_001165375.1
,
XP_011532579.1
,
XP_016863038.1
,
XP_011532577.1
Guide to Pharmacology - Targets
3244
GeneCards
Q9Y4B6
HPA
ENSG00000145041-DCAF1
Ensembl
ENSG00000145041
,
ENSP00000506880
,
ENSP00000393183
,
ENST00000684031
,
ENST00000423656
,
ENSP00000421724
,
ENST00000504652
PRO
Q9Y4B6
Pharos - Targets
Q9Y4B6
PDB
8OG7
,
4Z8L
,
7SSE
,
8OG6
,
8OG5
,
6N45
,
8OO5
,
5JK7
,
6ZUE
,
8OG9
,
4P7I
,
7OKQ
,
8OG8
,
3WA0
,
7UFV
,
7V7B
,
8F8E
,
4CC9
,
4PXW
,
8OOD
,
8OGA
,
5AJA
,
7V7C
,
6ZX9
,
8OGC
,
8OGB
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y3Z3 SAMHD1
1
SAMHD1 [nucleoplasm]
(R-HSA-5624198)
0.544
2
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