CDH11 variant mRNA is translated to CDH11 variant protein isoform

Stable Identifier
R-HSA-9759516
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
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CDH11 variant mRNA is translated to CDH11 variant protein isoform
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The CDH11 variant mRNA encodes the 85 kDa CDH11 variant protein isoform (CDH11v or CDH11-2), 693 amino acids long. CDH11v includes the extracellular domain, with its five subdomains (ectodomains EC1-EC5), and two thirds of the transmembrane (TM) domain. It lacks the C-terminal third of the TM domain and the cytoplasmic (CP) domain (Okazaki et al. 1994, Kawaguchi et al. 1999).

CDH11 mRNA levels are downregulated by the microRNA miR-451a (Wang et al. 2020) and miR-200c-3p (Van der Goten et al. 2014). The 3'UTR sequence targeted by miR-451a and miR-200c-3p is present in both the canonical splicing isoform and the variant splicing isoform of CDH11.
Literature References
PubMed ID Title Journal Year
8163513 Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts

Okazaki, M, Kikuno, R, Tsujimura, A, Amann, E, Takeshita, S, Kudo, A, Kawai, S

J Biol Chem 1994
10320525 Expression and function of the splice variant of the human cadherin-11 gene in subordination to intact cadherin-11

Machinami, R, Takeshita, S, Kawaguchi, J, Kashima, T, Imai, T, Kudo, A

J Bone Miner Res 1999
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
miR-200c-3p RISC:CDH11 mRNA [cytosol] (Homo sapiens)
Active Unit
miR-200c-3p [cytosol]
Regulator
miR-451a RISC:CDH11 mRNA [cytosol] (Homo sapiens)
Active Unit
miR-451a [cytosol]
Authored
Orlic-Milacic, M  (2022-06-02)
Reviewed
Brasch, J  (2023-04-18)
Created
Orlic-Milacic, M  (2021-12-06)
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