NFE2L2 binds the SRXN1 gene

Stable Identifier
Reaction [binding]
Homo sapiens
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NFE2L2 binds its cognate anti-oxidant response element (ARE) in the promoter of the SRXN1 gene as assessed by ChIP to upregulate its expression (Malhotra et al, 2010; Macleod et al, 2009; Wu et al, 2011). SRXN1 contributes to the oxidative stress response by reducing cysteine-sulfinic acid bonds in members of the PRDX family after oxidative challenge (Chang et al, 2004; Woo et al, 2005).
Literature References
PubMed ID Title Journal Year
15590625 Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2-cys peroxiredoxins

Yang, JS, Woo, HA, Park, SJ, Chang, TS, Jeong, W, Park, KJ, Rhee, SG

J Biol Chem 2005
20460467 Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

Shyr, C, Srivastava, S, Wakabayashi, N, Wasserman, WW, Singh, A, Malhotra, D, Biswal, S, Happel, C, Portales-Casamar, E, Kensler, TW, Arenillas, D

Nucleic Acids Res 2010
21775727 Beneficial role of Nrf2 in regulating NADPH generation and consumption

Klaassen, CD, Wu, KC, Cui, JY

Toxicol Sci 2011
15448164 Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine

Woo, HA, Lee, SM, Chang, TS, Jeong, W, Park, S, Rhee, SG

J Biol Chem 2004
19608619 Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds

MacLeod, AK, Penning, TM, Plummer, SM, Igarashi, K, Hayes, JD, McMahon, M, Higgins, LG

Carcinogenesis 2009
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