Reactome | Addition of a bifurcating GlcNAc to the N-glycan by MGAT3

Addition of a bifurcating GlcNAc to the N-glycan by MGAT3

Stable Identifier

R-HSA-975926

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi lumen, Golgi membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - N-glycan antennae elongation in the medial/trans-Golgi (Homo sapiens)
        
        Reactions specific to the hybrid N-glycan synthesis pathway (Homo sapiens)
        
        Addition of a bifurcating GlcNAc to the N-glycan by MGAT3 (Homo sapiens)

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Addition of a bifurcating GlcNAc to the N-glycan by MGAT3

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The addition of a bisecting GlcNAc to a complex N-glycan by MGAT3 is one of the most important regulatory steps in N-glycosylation, directing the pathway toward the synthesis of complex and hybrid N-glycans. This addition changes the structure of the N-glycan and inhibits further modification by MGAT2, MGAT4, MGAT5A/B and FUT8. Defects in MGAT3 have been shown to be associated with predisposition to cancer and several developmental defects (Song et al 2010; Stanley 2002).

Literature References

PubMed ID	Title	Journal	Year
12417419	Biological consequences of overexpressing or eliminating N-acetylglucosaminyltransferase-TIII in the mouse Stanley, P	Biochim Biophys Acta	2002
20395209	The bisecting GlcNAc on N-glycans inhibits growth factor signaling and retards mammary tumor progression Aglipay, JA, Bernstein, JD, Stanley, P, Song, Y, Goswami, S	Cancer Res	2010