Reactome | LRP2 binds extracellular TCN2:RCbl

LRP2 binds extracellular TCN2:RCbl

Stable Identifier

R-HSA-9759209

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Plasma membrane-associated LRP2 (megalin, glycoprotein 330) complexed with LDLRAP1 (Low density lipoprotein receptor adapter protein 1, also known as ARH, Autosomal recessive hypercholesterolemia protein) in renal proximal tubule epithelial cells binds TCN2:RCbl (transcobalamin 2 protein bound to cobalamins (RCbl)) (Moestrup et al. 1996; Nagai et al. 2003; Shah et al. 2013). LRP2 is a member of the low density lipoprotein receptor family (Kounnas et al. 1995, Hjalm et al. 1996).

Literature References

PubMed ID	Title	Journal	Year
14528014	The adaptor protein ARH escorts megalin to and through endosomes Takeda, T, Meerloo, T, Nagai, M, Farquhar, MG	Mol Biol Cell	2003
7768901	Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin Brewer, BH, Stefansson, S, Harmony, JA, Loukinova, EB, Kounnas, MZ, Strickland, DK, Argraves, WS	J Biol Chem	1995
8706697	Cloning and sequencing of human gp330, a Ca(2+)-binding receptor with potential intracellular signaling properties Lundgren, S, Murray, E, Larsson, M, Crumley, G, Hellman, P, Akerstrom, G, Juhlin, C, Ek, B, Morse, B, Davis, H, Rask, L, Onyango, I, Harazim, W, Hjalm, G	Eur J Biochem	1996
23836931	ARH directs megalin to the endocytic recycling compartment to regulate its proteolysis and gene expression Taupin, V, Shah, M, Farquhar, MG, Baterina, OY	J Cell Biol	2013
8710919	Megalin-mediated endocytosis of transcobalamin-vitamin-B12 complexes suggests a role of the receptor in vitamin-B12 homeostasis Verroust, PJ, Birn, H, Sim, RB, Moestrup, SK, Christensen, EI, Fischer, PB, Nexø, E, Petersen, CM	Proc Natl Acad Sci U S A	1996