Reactome | Addition of galactose by beta 4-galactosyltransferases

Addition of galactose by beta 4-galactosyltransferases

Stable Identifier

R-HSA-975919

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - N-glycan antennae elongation in the medial/trans-Golgi (Homo sapiens)
        
        N-Glycan antennae elongation (Homo sapiens)
        
        Addition of galactose by beta 4-galactosyltransferases (Homo sapiens)

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Addition of galactose by beta 4-galactosyltransferases

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Addition of a galactose residue on N-acetylglucosamine. The family of beta 4-galactosyltransferases is composed by at least six known members with different K(m) and acceptor specifities (Guo S et al, 2001) and probably originated by duplication (Lo NW et al, 1998). B4GALT1 is associated with Congenital Disorder of Glycosylation of type IId (Hansske B et al, 2002), and is expressed as two splicing isoforms of which only one is localizated in the Golgi system (Lopez LC et al, 1991; Schaub BE et al, 2006). B4GALT2 is key in the regulation of proteins involved in neuronal development (Sasaki N et
al, 2005).

Literature References

PubMed ID	Title	Journal	Year
17021253	Transition of galactosyltransferase 1 from trans-Golgi cisterna to the trans-Golgi network is signal mediated Schaub, BE, Berger, B, Berger, EG, Rohrer, J	Mol Biol Cell	2006
11901181	Deficiency of UDP-galactose:N-acetylglucosamine beta-1,4-galactosyltransferase I causes the congenital disorder of glycosylation type IId Hansske, B, Thiel, C, Lübke, T, Hasilik, M, Höning, S, Peters, V, Heidemann, PH, Hoffmann, GF, Berger, EG, von Figura, K, Körner, C	J Clin Invest	2002
11588157	Galactosylation of N-linked oligosaccharides by human beta-1,4-galactosyltransferases I, II, III, IV, V, and VI expressed in Sf-9 cells Guo, S, Sato, T, Shirane, K, Furukawa, K	Glycobiology	2001
1714903	Evidence for a molecular distinction between Golgi and cell surface forms of beta 1,4-galactosyltransferase Lopez, LC, Youakim, A, Evans, SC, Shur, BD	J Biol Chem	1991
9597550	The expanding beta 4-galactosyltransferase gene family: messages from the databanks Lo, NW, Shaper, JH, Pevsner, J, Shaper, NL	Glycobiology	1998
15939404	beta4GalT-II is a key regulator of glycosylation of the proteins involved in neuronal development Sasaki, N, Manya, H, Okubo, R, Kobayashi, K, Ishida, H, Toda, T, Endo, T, Nishihara, S	Biochem Biophys Res Commun	2005