Addition of galactose by beta 4-galactosyltransferases

Stable Identifier
R-HSA-975919
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Addition of a galactose residue on N-acetylglucosamine. The family of beta 4-galactosyltransferases is composed by at least six known members with different K(m) and acceptor specifities (Guo S et al, 2001) and probably originated by duplication (Lo NW et al, 1998). B4GALT1 is associated with Congenital Disorder of Glycosylation of type IId (Hansske B et al, 2002), and is expressed as two splicing isoforms of which only one is localizated in the Golgi system (Lopez LC et al, 1991; Schaub BE et al, 2006). B4GALT2 is key in the regulation of proteins involved in neuronal development (Sasaki N et
al, 2005).

Literature References
PubMed ID Title Journal Year
11901181 Deficiency of UDP-galactose:N-acetylglucosamine beta-1,4-galactosyltransferase I causes the congenital disorder of glycosylation type IId

Hansske, B, Thiel, C, Lübke, T, Hasilik, M, Höning, S, Peters, V, Heidemann, PH, Hoffmann, GF, Berger, EG, von Figura, K, Körner, C

J Clin Invest 2002
17021253 Transition of galactosyltransferase 1 from trans-Golgi cisterna to the trans-Golgi network is signal mediated

Schaub, BE, Berger, B, Berger, EG, Rohrer, J

Mol Biol Cell 2006
11588157 Galactosylation of N-linked oligosaccharides by human beta-1,4-galactosyltransferases I, II, III, IV, V, and VI expressed in Sf-9 cells

Guo, S, Sato, T, Shirane, K, Furukawa, K

Glycobiology 2001
1714903 Evidence for a molecular distinction between Golgi and cell surface forms of beta 1,4-galactosyltransferase

Lopez, LC, Youakim, A, Evans, SC, Shur, BD

J Biol Chem 1991
9597550 The expanding beta 4-galactosyltransferase gene family: messages from the databanks

Lo, NW, Shaper, JH, Pevsner, J, Shaper, NL

Glycobiology 1998
15939404 beta4GalT-II is a key regulator of glycosylation of the proteins involved in neuronal development

Sasaki, N, Manya, H, Okubo, R, Kobayashi, K, Ishida, H, Toda, T, Endo, T, Nishihara, S

Biochem Biophys Res Commun 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity of B4GALT1-6 homodimers [Golgi membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created