Addition of galactose by beta 4-galactosyltransferases

Stable Identifier
Reaction [transition]
Homo sapiens
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Addition of a galactose residue on N-acetylglucosamine. The family of beta 4-galactosyltransferases is composed by at least six known members with different K(m) and acceptor specifities (Guo S et al, 2001) and probably originated by duplication (Lo NW et al, 1998). B4GALT1 is associated with Congenital Disorder of Glycosylation of type IId (Hansske B et al, 2002), and is expressed as two splicing isoforms of which only one is localizated in the Golgi system (Lopez LC et al, 1991; Schaub BE et al, 2006). B4GALT2 is key in the regulation of proteins involved in neuronal development (Sasaki N et
al, 2005).
Literature References
PubMed ID Title Journal Year
17021253 Transition of galactosyltransferase 1 from trans-Golgi cisterna to the trans-Golgi network is signal mediated

Rohrer, J, Berger, B, Berger, EG, Schaub, BE

Mol Biol Cell 2006
11901181 Deficiency of UDP-galactose:N-acetylglucosamine beta-1,4-galactosyltransferase I causes the congenital disorder of glycosylation type IId

Hoffmann, GF, Lübke, T, Peters, V, Hansske, B, Körner, C, Heidemann, PH, von Figura, K, Berger, EG, Höning, S, Thiel, C, Hasilik, M

J Clin Invest 2002
11588157 Galactosylation of N-linked oligosaccharides by human beta-1,4-galactosyltransferases I, II, III, IV, V, and VI expressed in Sf-9 cells

Guo, S, Sato, T, Furukawa, K, Shirane, K

Glycobiology 2001
1714903 Evidence for a molecular distinction between Golgi and cell surface forms of beta 1,4-galactosyltransferase

Shur, BD, Lopez, LC, Youakim, A, Evans, SC

J Biol Chem 1991
9597550 The expanding beta 4-galactosyltransferase gene family: messages from the databanks

Pevsner, J, Shaper, NL, Shaper, JH, Lo, NW

Glycobiology 1998
15939404 beta4GalT-II is a key regulator of glycosylation of the proteins involved in neuronal development

Kobayashi, K, Sasaki, N, Okubo, R, Endo, T, Toda, T, Ishida, H, Nishihara, S, Manya, H

Biochem Biophys Res Commun 2005
Catalyst Activity

beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity of B4GALT1-6 homodimers [Golgi membrane]

Orthologous Events
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