NFE2L2-dependent PRDX1 gene expression

Stable Identifier
R-HSA-9759189
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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NFE2L2-dependent PRDX1 gene expression
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PRDX1 encodes a thiol-specific peroxidase that contributes to cytoprotection by reducing hydrogen peroxide and other hydroperoxides to water and alcohols (reviewed in Ding et al, 2017; Ledgerwood et al, 2017). PRDX1 expression is stimulated downstream of the NFE2L2-KEAP1 pathway in response to oxidative and electrophilic stressors (Ishii et al, 2000; Kwak et al, 2003). Consistent with this, NFE2L2 binds to its cognate element in the PRDX1 promoter as assessed by electrophoretic mobility shift (EMSA) assay and chromatin immunoprecipitation (ChIP) in response to hypoxia (Kim et al, 2007; reviewed in Baird and Yamamoto, 2020).
Literature References
PubMed ID Title Journal Year
32284348 The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

Yamamoto, M, Baird, L

Mol Cell Biol 2020
17234762 Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: implication to tumor biology

Park, YM, Ahn, JY, Ip, C, Kim, YJ, Zhang, Y, Liang, P

Cancer Res 2007
12506115 Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival

Motohashi, H, Yamamoto, M, Wakabayashi, N, Itoh, K, Kwak, MK, Kensler, TW

J Biol Chem 2003
10821856 Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

Ishii, T, Sato, H, Yamamoto, M, Takahashi, S, Yanagawa, T, Bannai, S, Itoh, K, Katoh, Y

J Biol Chem 2000
27653015 Peroxiredoxin 1 - an antioxidant enzyme in cancer

Ding, C, Fan, X, Wu, G

J Cell Mol Med 2017
27756681 The role of peroxiredoxin 1 in redox sensing and transducing

Ledgerwood, EC, Marshall, JW, Weijman, JF

Arch Biochem Biophys 2017
Participants
Input
Output
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as an event of
This event is regulated
Positively by
Regulator
PRDX1 gene:p-NFE2L2 [nucleoplasm] (Homo sapiens)
Active Unit
p-NFE2L2 [nucleoplasm]
Authored
Rothfels, K  (2021-10-08)
Reviewed
Cuadrado, A  (2022-02-23)
Created
Rothfels, K  (2021-11-29)
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