NFE2L2-dependent HMOX1 gene expression

Stable Identifier
R-HSA-9759176
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, endoplasmic reticulum membrane
ReviewStatus
5/5
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NFE2L2-dependent HMOX1 gene expression
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NFE2L2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that activates transcription of a battery of cytoprotective genes by binding to the ARE (antioxidant response element). It is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. HMOX1 is one of the genes whose expression it activates (Reichard et al, 2007; Ishii et al, 2002; reviewed in Baird and Yamamoto, 2020).
Literature References
PubMed ID Title Journal Year
17942419 Heme oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1

Puga, A, Reichard, JF, Motz, GT

Nucleic Acids Res 2007
32284348 The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

Yamamoto, M, Baird, L

Mol Cell Biol 2020
10821856 Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

Ishii, T, Sato, H, Yamamoto, M, Takahashi, S, Yanagawa, T, Bannai, S, Itoh, K, Katoh, Y

J Biol Chem 2000
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
BACH1:MAFK [nucleoplasm] (Homo sapiens)
Positively by
Regulator
HMOX1 gene:p-NFE2L2:MAFK [nucleoplasm] (Homo sapiens)
Active Unit
MAFK [nucleoplasm]
p-NFE2L2 [nucleoplasm]
Authored
Rothfels, K  (2021-10-08)
Reviewed
Cuadrado, A  (2022-02-23)
Created
Rothfels, K  (2021-11-29)
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