NFE2L2 binds to its consensus sequence in the promoter of the PRDX1 gene to stimulate expression downstream of hypoxia, antioxidant and electrophilic stressors (Ishii et al, 2000; Kwak et al, 2003; Kim et al, 2007; reviewed in Baird and Yamamoto, 2020). PRDX1 protein contributes to stress response through the reduction of hydrogen peroxide and other substrates (reviewed in Ding et al, 2017; Ledgerwood et al, 2017).
Yamamoto, M, Baird, L
Park, YM, Ahn, JY, Ip, C, Kim, YJ, Zhang, Y, Liang, P
Motohashi, H, Yamamoto, M, Wakabayashi, N, Itoh, K, Kwak, MK, Kensler, TW
Ding, C, Fan, X, Wu, G
Ishii, T, Sato, H, Yamamoto, M, Takahashi, S, Yanagawa, T, Bannai, S, Itoh, K, Katoh, Y
Ledgerwood, EC, Marshall, JW, Weijman, JF
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