NFE2L2 binds the PRDX1 promoter

Stable Identifier
R-HSA-9759129
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
NFE2L2 binds the PRDX1 promoter
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
NFE2L2 binds to its consensus sequence in the promoter of the PRDX1 gene to stimulate expression downstream of hypoxia, antioxidant and electrophilic stressors (Ishii et al, 2000; Kwak et al, 2003; Kim et al, 2007; reviewed in Baird and Yamamoto, 2020). PRDX1 protein contributes to stress response through the reduction of hydrogen peroxide and other substrates (reviewed in Ding et al, 2017; Ledgerwood et al, 2017).
Literature References
PubMed ID Title Journal Year
32284348 The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

Baird, L, Yamamoto, M

Mol Cell Biol 2020
17234762 Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: implication to tumor biology

Kim, YJ, Ahn, JY, Liang, P, Ip, C, Zhang, Y, Park, YM

Cancer Res 2007
12506115 Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival

Kwak, MK, Wakabayashi, N, Itoh, K, Motohashi, H, Yamamoto, M, Kensler, TW

J Biol Chem 2003
27653015 Peroxiredoxin 1 - an antioxidant enzyme in cancer

Ding, C, Fan, X, Wu, G

J Cell Mol Med 2017
10821856 Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

Ishii, T, Itoh, K, Takahashi, S, Sato, H, Yanagawa, T, Katoh, Y, Bannai, S, Yamamoto, M

J Biol Chem 2000
27756681 The role of peroxiredoxin 1 in redox sensing and transducing

Ledgerwood, EC, Marshall, JW, Weijman, JF

Arch Biochem Biophys 2017
Participants
Input
Output
Participates
as an event of
Authored
Rothfels, K  (2021-10-08)
Reviewed
Cuadrado, A  (2022-02-23)
Created
Rothfels, K  (2021-11-29)
Cite Us!