NFE2L2 binds the PRDX1 promoter

Stable Identifier
R-HSA-9759129
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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NFE2L2 binds the PRDX1 promoter
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NFE2L2 binds to its consensus sequence in the promoter of the PRDX1 gene to stimulate expression downstream of hypoxia, antioxidant and electrophilic stressors (Ishii et al, 2000; Kwak et al, 2003; Kim et al, 2007; reviewed in Baird and Yamamoto, 2020). PRDX1 protein contributes to stress response through the reduction of hydrogen peroxide and other substrates (reviewed in Ding et al, 2017; Ledgerwood et al, 2017).

Literature References
PubMed ID Title Journal Year
32284348 The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

Yamamoto, M, Baird, L

Mol Cell Biol 2020
17234762 Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: implication to tumor biology

Park, YM, Ahn, JY, Ip, C, Kim, YJ, Zhang, Y, Liang, P

Cancer Res 2007
12506115 Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival

Motohashi, H, Yamamoto, M, Wakabayashi, N, Itoh, K, Kwak, MK, Kensler, TW

J Biol Chem 2003
27653015 Peroxiredoxin 1 - an antioxidant enzyme in cancer

Ding, C, Fan, X, Wu, G

J Cell Mol Med 2017
10821856 Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

Ishii, T, Sato, H, Yamamoto, M, Takahashi, S, Yanagawa, T, Bannai, S, Itoh, K, Katoh, Y

J Biol Chem 2000
27756681 The role of peroxiredoxin 1 in redox sensing and transducing

Ledgerwood, EC, Marshall, JW, Weijman, JF

Arch Biochem Biophys 2017
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Authored
Rothfels, K  (2021-10-08)
Reviewed
Cuadrado, A  (2022-02-23)
Created
Rothfels, K  (2021-11-29)
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