Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
ST6GAL1 [Golgi membrane]
Stable Identifier
R-HSA-975899
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi membrane
Synonyms
Beta-galactoside alpha-2,6-sialyltransferase 1, SIAT1_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
Translation of Structural Proteins (Homo sapiens)
Maturation of protein 3a (Homo sapiens)
O-glycosylation of 3a is terminated (Homo sapiens)
sialyltransferases [Golgi membrane] (Homo sapiens)
ST6GAL1 [Golgi membrane] (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Late SARS-CoV-2 Infection Events (Homo sapiens)
Translation of Structural Proteins (Homo sapiens)
Maturation of protein 3a (Homo sapiens)
O-glycosylation of 3a is terminated (Homo sapiens)
sialyltransferases [Golgi membrane] (Homo sapiens)
ST6GAL1 [Golgi membrane] (Homo sapiens)
Maturation of spike protein (Homo sapiens)
Addition of sialic acids on some Spike glycosyl sidechains (Homo sapiens)
sialyltransferases [Golgi membrane] (Homo sapiens)
ST6GAL1 [Golgi membrane] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
Sialic acid metabolism (Homo sapiens)
ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) (Homo sapiens)
ST6GAL1,2 [Golgi membrane] (Homo sapiens)
ST6GAL1 [Golgi membrane] (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
N-glycan antennae elongation in the medial/trans-Golgi (Homo sapiens)
N-Glycan antennae elongation (Homo sapiens)
ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans (Homo sapiens)
ST6GAL1 [Golgi membrane] (Homo sapiens)
O-linked glycosylation (Homo sapiens)
O-linked glycosylation of mucins (Homo sapiens)
Termination of O-glycan biosynthesis (Homo sapiens)
ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens (Homo sapiens)
ST6GAL1 [Golgi membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P15907 ST6GAL1
Gene Names
ST6GAL1, SIAT1
Chain
chain:1-406
Reference Genes
BioGPS Gene:6480 ST6GAL1
COSMIC (genes):ST6GAL1 ST6GAL1
CTD Gene:6480 ST6GAL1
dbSNP Gene:6480 ST6GAL1
ENSEMBL:ENSG00000073849 ST6GAL1
HGNC:10860 ST6GAL1
KEGG:hsa:6480 ST6GAL1
Monarch:6480 ST6GAL1
NCBI Gene:6480 ST6GAL1
OMIM:109675 ST6GAL1
UCSC:P15907 ST6GAL1
Reference Transcript
RefSeq:NM_003032.2 ST6GAL1
RefSeq:XM_017007068.1 ST6GAL1
RefSeq:XM_006713734.1 ST6GAL1
RefSeq:XM_017007067.1 ST6GAL1
RefSeq:XM_011513085.1 ST6GAL1
RefSeq:XM_017007066.1 ST6GAL1
RefSeq:NM_173216.2 ST6GAL1
RefSeq:NM_173217.2 ST6GAL1
RefSeq:XM_011513086.1 ST6GAL1
RefSeq:XM_017007065.1 ST6GAL1
RefSeq:XM_005247719.1 ST6GAL1
RefSeq:XM_005247720.1 ST6GAL1
Other Identifiers
11717719_a_at
11717720_a_at
11717721_s_at
201998_PM_at
201998_at
214971_PM_s_at
214971_s_at
2656807
2656838
2656839
2656840
2656841
2656842
2656843
2656844
2656847
2656848
2656849
2656850
2656853
2656855
2656856
2656857
2656858
2656859
2656860
2656861
2656862
2656863
2656864
2656865
2656866
2656867
2656868
2656869
2656870
2656881
2656906
2656920
2656933
2656949
41352_at
6480
8084717
89978_s_at
A_14_P103427
A_14_P113952
A_14_P120432
A_24_P388528
A_33_P3382276
GE59883
GE625428
GE88127
GO:0000138
GO:0000139
GO:0002376
GO:0003824
GO:0003835
GO:0005515
GO:0005576
GO:0005794
GO:0005797
GO:0006054
GO:0006486
GO:0006959
GO:0008373
GO:0016020
GO:0016266
GO:0016740
GO:0016757
GO:0018279
GO:0019082
GO:0032580
GO:0032946
GO:0042803
GO:0043226
GO:0045471
GO:0050922
GO:0097503
GO:1900024
GO:1901135
GO:2000110
HMNXSV003012803
HMNXSV003020109
HMNXSV003024913
Hs.2554.0.A2_3p_at
Hs.2554.1.S1_3p_a_at
ILMN_1653120
ILMN_1756501
ILMN_2384496
PH_hs_0000340
PH_hs_0039743
TC03002711.hg
X62822_at
Participates
as a member of
sialyltransferases [Golgi membrane] (Homo sapiens)
ST6GAL1,2 [Golgi membrane] (Homo sapiens)
Inferred To
SiaT [Golgi membrane]
(Drosophila melanogaster)
st6gal1 [Golgi membrane]
(Xenopus tropicalis)
ST6GAL1 [Golgi membrane]
(Bos taurus)
ST6GAL1 [Golgi membrane]
(Canis familiaris)
ST6GAL1 [Golgi membrane]
(Gallus gallus)
ST6GAL1 [Golgi membrane]
(Mus musculus)
ST6GAL1 [Golgi membrane]
(Rattus norvegicus)
ST6GAL1 [Golgi membrane]
(Sus scrofa)
Cross References
RefSeq
XP_016862555.1
,
XP_011511388.1
,
XP_016862556.1
,
XP_016862554.1
,
XP_011511387.1
,
NP_003023.1
,
NP_775323.1
,
NP_775324.1
,
XP_006713797.1
,
XP_005247776.1
,
XP_016862557.1
,
XP_005247777.1
OpenTargets
ENSG00000073849
ENSEMBL
ENSP00000412221
,
ENSG00000073849
,
ENSP00000504448
,
ENST00000457772
,
ENST00000416235
,
ENSP00000503457
,
ENST00000677292
,
ENSP00000414504
,
ENSP00000169298
,
ENST00000169298
,
ENSP00000389337
,
ENST00000676633
,
ENST00000448044
HPA
ENSG00000073849-ST6GAL1
GeneCards
ST6GAL1
PRO
P15907
Pharos - Targets
P15907
GlyGen
P15907
PDB
4JS2
,
4JS1
,
6QVT
,
6QVS
HMDB Protein
HMDBP11956
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q5TH69 BIG3
0.527
2
UniProt:Q96RQ1 ERGI2
0.527
2
UniProt:Q96ER3 SAAL1
0.527
2
UniProt:Q9C0D3 ZY11B
0.527
2
UniProt:P48426 PIP4K2A
2
PIP4K2A [cytosol]
(R-HSA-1604641)
PIP4K2A [nucleoplasm]
(R-HSA-6811484)
0.527
2
UniProt:Q92990 GLMN
1
GLMN [cytosol]
(R-HSA-8951779)
0.527
2
UniProt:Q6P2P2 ANM9
0.527
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text