Unknown efflux pump transports glucuronidated PRED metabolite

Stable Identifier
R-HSA-9758868
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Unknown efflux pump transports glucuronidated PRED metabolite
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Since glucuronide conjugates are hydrophilic, efflux transporters mediate their excretion from tissues. It is not known which transporter is responsible for hepatic efflux of glucuronidated prednisone (PREDN) metabolites. The possible candidates are ABCC2 and ABCC3 which also export steroid hormone glucuronides from liver cells (Järvinen et al, 2018; Järvinen et al, 2019).
Literature References
PubMed ID Title Journal Year
29175180 Efflux transport of estrogen glucuronides by human MRP2, MRP3, MRP4 and BCRP

Finel, M, Deng, F, Järvinen, E, Kidron, H

J Steroid Biochem Mol Biol 2018
31704245 Human efflux transport of testosterone, epitestosterone and other androgen glucuronides

Finel, M, Järvinen, E, Kidron, H

J Steroid Biochem Mol Biol 2020
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
xenobiotic transmembrane transport (0006855)
Authored
Stephan, R  (2021-11-26)
Reviewed
Thorn, CF  (2022-08-05)
Created
Stephan, R  (2021-11-26)
Cite Us!