Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex

Stable Identifier
R-HSA-975874
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Escherichia coli
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Second, Thr387 in the activation loop is phosphorylated, leading to full enzymatic activity.
Literature References
PubMed ID Title Journal Year
14625308 Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling

Wesche, H, Li, S, Martin, MU, Knop, J, Neumann, D, Cao, P, Mackensen, AC, Kollewe, C

J Biol Chem 2004
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-IRAK1:p-IRAK4:oligo-MyD88l:activated TLR5 or 10 [plasma membrane]

Authored
Reviewed
Created
Cite Us!