IRAK4 binds to MyD88 bound to the activated TLR5 or 10 receptor

Stable Identifier
Reaction [binding]
Homo sapiens
Related Species
Escherichia coli
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IRAK4 is the mammalian homolog of Drosophila melanogaster Tube [Towb P et al 2009; Moncrieffe MC et al 2008]. Like Tube, IRAK4 possesses a conserved N-terminal death domain (DD), which mediates interactions with MyD88 at one binding site and a downstream IRAK kinase at the other, thereby bridging MyD88 and IRAK1/2 association [Towb P et al 2009; Lin SC e al 2010]. IRAK-4 plays a critical role in Toll receptor signaling - any interference with IRAK-4's kinase activity virtually abolishes downstream events. This is not the case with other members of the IRAK family [Suzuki N et al 2002; Li S et al 2002].

Literature References
PubMed ID Title Journal Year
12297423 IRAK-4 as the central TIR signaling mediator in innate immunity

Suzuki, S, Yeh, WC, Suzuki, N

Trends Immunol 2002
11960013 IRAK-4: a novel member of the IRAK family with the properties of an

Wesche, H, Li, S, Fontana, EJ, Strelow, A

Proc Natl Acad Sci U S A 2002
Orthologous Events
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