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p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane]
Stable Identifier
R-HSA-975870
Type
Complex
Species
Homo sapiens
Related Species
Escherichia coli
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88 :activated TLR5 or 10 [plasma membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 : pIRAK4:MyD88:activated TLR5/10 [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR (Homo sapiens)
IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR5/10 [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88l:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex (Homo sapiens)
IRAK1 or IRAK2 :p-IRAK4:MyD88 oligomer:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
IRAK4 autophosphorylation within the complex activated TLR:MyD88 (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR (Homo sapiens)
hp-IRAK1:activated IRAK4:MyD88oligomer:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88 :activated TLR5 or 10 complex [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex (Homo sapiens)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:activated TLR5/10 [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88l:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88 :activated TLR5 or 10 complex [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
TRAF6 binds to hp- IRAK1 or p-IRAK2 (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88 :activated TLR5 or 10 [plasma membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 : pIRAK4:MyD88:activated TLR5/10 [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 : pIRAK4:MyD88:activated TLR5/10 [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88 :activated TLR5 or 10 [plasma membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 : pIRAK4:MyD88:activated TLR5/10 [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR (Homo sapiens)
IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR5/10 [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88l:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex (Homo sapiens)
IRAK1 or IRAK2 :p-IRAK4:MyD88 oligomer:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
IRAK4 autophosphorylation within the complex activated TLR:MyD88 (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR (Homo sapiens)
hp-IRAK1:activated IRAK4:MyD88oligomer:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88 :activated TLR5 or 10 complex [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex (Homo sapiens)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:activated TLR5/10 [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88l:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88 :activated TLR5 or 10 complex [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
TRAF6 binds to hp- IRAK1 or p-IRAK2 (Homo sapiens)
TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88 :activated TLR5 or 10 [plasma membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 : pIRAK4:MyD88:activated TLR5/10 [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 : pIRAK4:MyD88:activated TLR5/10 [plasma membrane] (Homo sapiens)
p-S,2T-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
Participants
components
oligo-MyD88:activated TLR5 or 10 [plasma membrane]
(Homo sapiens)
x 4
p-T342,T345,S346-IRAK4 [plasma membrane]
(Homo sapiens)
Participates
as a component of
p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
IRAK2:p-S,2T-IRAK4:oligo-MyD88:activated TLR5/10 [plasma membrane] (Homo sapiens)
IRAK1 or IRAK2 :p-IRAK4:MyD88 oligomer:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR5/10 [plasma membrane] (Homo sapiens)
p-IRAK1:p-IRAK4:oligo-MyD88l:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
hp-IRAK1:activated IRAK4:MyD88oligomer:activated TLR5 or 10 [plasma membrane] (Homo sapiens)
pp-IRAK1:p-IRAK4:oligo-MyD88 :activated TLR5 or 10 complex [plasma membrane] (Homo sapiens)
hp-IRAK1 or p-IRAK2 : pIRAK4:MyD88:activated TLR5/10 [plasma membrane] (Homo sapiens)
as an output of
IRAK4 autophosphorylation within the complex activated TLR:MyD88 (Homo sapiens)
Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex (Homo sapiens)
as an input of
IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex (Homo sapiens)
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